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Ring-like N-fold Models of Aβ(42) fibrils
When assembling as fibrils Aβ(40) peptides can only assume U-shaped conformations while Aβ(42) can also arrange as S-shaped three-stranded chains. We show that this allows Aβ(42) peptides to assemble pore-like structures that may explain their higher toxicity. For this purpose, we develop a scalable...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529447/ https://www.ncbi.nlm.nih.gov/pubmed/28747632 http://dx.doi.org/10.1038/s41598-017-06846-0 |