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PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints

In rheumatoid arthritis (RA), the proliferation of fibroblast-like synoviocytes (FLS) is the cause of chronic inflammation in joints and of joint damage. Delivery of the pro-apoptotic gene PUMA to FLS via human adenovirus type 5 (HAdV5) vectors has been tested as a therapeutic approach, but efficien...

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Detalles Bibliográficos
Autores principales:	Hong, Saw-See, Marotte, Hubert, Courbon, Guillaume, Firestein, Gary S., Boulanger, Pierre, Miossec, Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529536/ https://www.ncbi.nlm.nih.gov/pubmed/28747638 http://dx.doi.org/10.1038/s41467-017-00142-1

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