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Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia

Several Cirsium species are known for their uses in traditional medicine and consequently are studied for their phytochemical content and their biological activities. In the framework of a previous study conducted on eight extremophile plants from Tunisia, we highlighted that the crude methanolic ex...

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Autores principales: Sahli, Ramla, Rivière, Céline, Dufloer, Cédric, Beaufay, Claire, Neut, Christel, Bero, Joanne, Hennebelle, Thierry, Roumy, Vincent, Ksouri, Riadh, Quetin-Leclercq, Joelle, Sahpaz, Sevser
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529658/
https://www.ncbi.nlm.nih.gov/pubmed/28785293
http://dx.doi.org/10.1155/2017/7247016
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author Sahli, Ramla
Rivière, Céline
Dufloer, Cédric
Beaufay, Claire
Neut, Christel
Bero, Joanne
Hennebelle, Thierry
Roumy, Vincent
Ksouri, Riadh
Quetin-Leclercq, Joelle
Sahpaz, Sevser
author_facet Sahli, Ramla
Rivière, Céline
Dufloer, Cédric
Beaufay, Claire
Neut, Christel
Bero, Joanne
Hennebelle, Thierry
Roumy, Vincent
Ksouri, Riadh
Quetin-Leclercq, Joelle
Sahpaz, Sevser
author_sort Sahli, Ramla
collection PubMed
description Several Cirsium species are known for their uses in traditional medicine and consequently are studied for their phytochemical content and their biological activities. In the framework of a previous study conducted on eight extremophile plants from Tunisia, we highlighted that the crude methanolic extract of C. scabrum, a not investigated thistle, showed moderate but quite selective cytotoxic activity against the cancerous cell line J774 compared to the noncancerous cell line WI38 (IC(50) = 11.53 μg/ml on J774, IC(50) = 29.89 µg/ml on WI38, and selectivity index = 2.6). In the current study, the partitions of the leaves of C. scabrum were analyzed for their antiproliferative activity on the same cell lines. From the most active petroleum ether partition, we isolated four triterpenoids including lupeol, taraxasterol acetate, and a (1 : 1) mixture of 25-hydroperoxycycloart-23-en-3β-ol and 24-hydroperoxycycloart-25-en-3β-ol. These two cycloartane-type triterpenoids are mostly responsible for this cytotoxic activity. On the other hand, the antimicrobial potential of this plant was also evaluated against 36 microorganisms. The moderate antibacterial activity against 6 Staphylococcus aureus and 2 Dermabacter hominis strains is mainly attributed to the butanol partition whose major compounds are glycosides of flavones.
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spelling pubmed-55296582017-08-07 Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia Sahli, Ramla Rivière, Céline Dufloer, Cédric Beaufay, Claire Neut, Christel Bero, Joanne Hennebelle, Thierry Roumy, Vincent Ksouri, Riadh Quetin-Leclercq, Joelle Sahpaz, Sevser Evid Based Complement Alternat Med Research Article Several Cirsium species are known for their uses in traditional medicine and consequently are studied for their phytochemical content and their biological activities. In the framework of a previous study conducted on eight extremophile plants from Tunisia, we highlighted that the crude methanolic extract of C. scabrum, a not investigated thistle, showed moderate but quite selective cytotoxic activity against the cancerous cell line J774 compared to the noncancerous cell line WI38 (IC(50) = 11.53 μg/ml on J774, IC(50) = 29.89 µg/ml on WI38, and selectivity index = 2.6). In the current study, the partitions of the leaves of C. scabrum were analyzed for their antiproliferative activity on the same cell lines. From the most active petroleum ether partition, we isolated four triterpenoids including lupeol, taraxasterol acetate, and a (1 : 1) mixture of 25-hydroperoxycycloart-23-en-3β-ol and 24-hydroperoxycycloart-25-en-3β-ol. These two cycloartane-type triterpenoids are mostly responsible for this cytotoxic activity. On the other hand, the antimicrobial potential of this plant was also evaluated against 36 microorganisms. The moderate antibacterial activity against 6 Staphylococcus aureus and 2 Dermabacter hominis strains is mainly attributed to the butanol partition whose major compounds are glycosides of flavones. Hindawi 2017 2017-07-12 /pmc/articles/PMC5529658/ /pubmed/28785293 http://dx.doi.org/10.1155/2017/7247016 Text en Copyright © 2017 Ramla Sahli et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sahli, Ramla
Rivière, Céline
Dufloer, Cédric
Beaufay, Claire
Neut, Christel
Bero, Joanne
Hennebelle, Thierry
Roumy, Vincent
Ksouri, Riadh
Quetin-Leclercq, Joelle
Sahpaz, Sevser
Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia
title Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia
title_full Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia
title_fullStr Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia
title_full_unstemmed Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia
title_short Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia
title_sort antiproliferative and antibacterial activities of cirsium scabrum from tunisia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529658/
https://www.ncbi.nlm.nih.gov/pubmed/28785293
http://dx.doi.org/10.1155/2017/7247016
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