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Cadmium inhibits mismatch repair by blocking the ATPase activity of the MSH2–MSH6 complex
Cadmium (Cd(2+)) is a known carcinogen that inactivates the DNA mismatch repair (MMR) pathway. In this study, we have tested the effect of Cd(2+) exposure on the enzymatic activity of the mismatch binding complex MSH2–MSH6. Our results indicate that Cd(2+) is highly inhibitory to the ATP binding and...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC552968/ https://www.ncbi.nlm.nih.gov/pubmed/15746000 http://dx.doi.org/10.1093/nar/gki291 |
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