Translational Modeling to Guide Study Design and Dose Choice in Obesity Exemplified by AZD1979, a Melanin‐concentrating Hormone Receptor 1 Antagonist

In this study, we present the translational modeling used in the discovery of AZD1979, a melanin‐concentrating hormone receptor 1 (MCHr1) antagonist aimed for treatment of obesity. The model quantitatively connects the relevant biomarkers and thereby closes the scaling path from rodent to man, as we...

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Detalles Bibliográficos
Autores principales: Gennemark, P, Trägårdh, M, Lindén, D, Ploj, K, Johansson, A, Turnbull, A, Carlsson, B, Antonsson, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529746/
https://www.ncbi.nlm.nih.gov/pubmed/28556607
http://dx.doi.org/10.1002/psp4.12199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529746/
https://www.ncbi.nlm.nih.gov/pubmed/28556607
http://dx.doi.org/10.1002/psp4.12199

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