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Expression and clinical significance of cyclooxygenase 2 and survivin in human gliomas
The present study aimed to determine cyclooxygenase 2 (COX-2) and survivin expression levels in glioma tissues, and to investigate their association with clinicopathological factors and patient survival. Immunohistochemistry was performed to evaluate COX-2 and survivin expression levels in paraffin-...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529877/ https://www.ncbi.nlm.nih.gov/pubmed/28789345 http://dx.doi.org/10.3892/ol.2017.6281 |
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author | Zhang, Fan Chu, Jinjin Wang, Fan |
author_facet | Zhang, Fan Chu, Jinjin Wang, Fan |
author_sort | Zhang, Fan |
collection | PubMed |
description | The present study aimed to determine cyclooxygenase 2 (COX-2) and survivin expression levels in glioma tissues, and to investigate their association with clinicopathological factors and patient survival. Immunohistochemistry was performed to evaluate COX-2 and survivin expression levels in paraffin-embedded surgically resected tissues from 70 patients with glioma and 7 individuals with normal brain tissues. The association between COX-2 and survivin expression levels and clinicopathological features was investigated using the χ(2) test, and the survival time was analyzed using the Kaplan Meier method with log-rank test. COX-2 and survivin were overexpressed in glioma tissues, and higher expression levels were observed in glioma tissues of histological grades III–IV compared with those in grade I–II tumor tissues (P<0.05); however, the expression levels were not associated with gender, age, tumor size or location (P>0.05). There was a significant positive association between the expression levels of COX-2 and survivin in the glioma tissues. Additionally, COX-2 and survivin expression levels were significantly negatively correlated with the rate of survival. In conclusion, COX-2 and survivin expression is positively associated with the pathological grade of a glioma and may contribute to glioma tumorigenesis. Therefore, COX-2 and survivin may be sensitive predictors of a negative clinical prognosis for patients with glioma. |
format | Online Article Text |
id | pubmed-5529877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-55298772017-08-07 Expression and clinical significance of cyclooxygenase 2 and survivin in human gliomas Zhang, Fan Chu, Jinjin Wang, Fan Oncol Lett Articles The present study aimed to determine cyclooxygenase 2 (COX-2) and survivin expression levels in glioma tissues, and to investigate their association with clinicopathological factors and patient survival. Immunohistochemistry was performed to evaluate COX-2 and survivin expression levels in paraffin-embedded surgically resected tissues from 70 patients with glioma and 7 individuals with normal brain tissues. The association between COX-2 and survivin expression levels and clinicopathological features was investigated using the χ(2) test, and the survival time was analyzed using the Kaplan Meier method with log-rank test. COX-2 and survivin were overexpressed in glioma tissues, and higher expression levels were observed in glioma tissues of histological grades III–IV compared with those in grade I–II tumor tissues (P<0.05); however, the expression levels were not associated with gender, age, tumor size or location (P>0.05). There was a significant positive association between the expression levels of COX-2 and survivin in the glioma tissues. Additionally, COX-2 and survivin expression levels were significantly negatively correlated with the rate of survival. In conclusion, COX-2 and survivin expression is positively associated with the pathological grade of a glioma and may contribute to glioma tumorigenesis. Therefore, COX-2 and survivin may be sensitive predictors of a negative clinical prognosis for patients with glioma. D.A. Spandidos 2017-08 2017-05-31 /pmc/articles/PMC5529877/ /pubmed/28789345 http://dx.doi.org/10.3892/ol.2017.6281 Text en Copyright: © Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Zhang, Fan Chu, Jinjin Wang, Fan Expression and clinical significance of cyclooxygenase 2 and survivin in human gliomas |
title | Expression and clinical significance of cyclooxygenase 2 and survivin in human gliomas |
title_full | Expression and clinical significance of cyclooxygenase 2 and survivin in human gliomas |
title_fullStr | Expression and clinical significance of cyclooxygenase 2 and survivin in human gliomas |
title_full_unstemmed | Expression and clinical significance of cyclooxygenase 2 and survivin in human gliomas |
title_short | Expression and clinical significance of cyclooxygenase 2 and survivin in human gliomas |
title_sort | expression and clinical significance of cyclooxygenase 2 and survivin in human gliomas |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529877/ https://www.ncbi.nlm.nih.gov/pubmed/28789345 http://dx.doi.org/10.3892/ol.2017.6281 |
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