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Negative feedback loop between ZBTB7A and TGF-β in breast cancer

Zinc finger and BTB domain containing 7A (ZBTB7A) is aberrantly expressed in breast cancer, but the involvement of ZBTB7A in breast cancer remains controversial. Transforming growth factor-β (TGF-β) is a pleiotropic cytokine which promotes breast cancer metastasis. ZBTB7A and TGF-β are important fac...

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Autores principales: Shen, Yingying, Cao, Renxian, Liu, Wen, Zhou, Yuqing, Wu, Ying, Tan, Jingjing, Jin, Min, Zhong, Jing, Zhang, Qinghai, Liu, Jianghua, Zu, Xuyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529933/
https://www.ncbi.nlm.nih.gov/pubmed/28789356
http://dx.doi.org/10.3892/ol.2017.6291
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author Shen, Yingying
Cao, Renxian
Liu, Wen
Zhou, Yuqing
Wu, Ying
Tan, Jingjing
Jin, Min
Zhong, Jing
Zhang, Qinghai
Liu, Jianghua
Zu, Xuyu
author_facet Shen, Yingying
Cao, Renxian
Liu, Wen
Zhou, Yuqing
Wu, Ying
Tan, Jingjing
Jin, Min
Zhong, Jing
Zhang, Qinghai
Liu, Jianghua
Zu, Xuyu
author_sort Shen, Yingying
collection PubMed
description Zinc finger and BTB domain containing 7A (ZBTB7A) is aberrantly expressed in breast cancer, but the involvement of ZBTB7A in breast cancer remains controversial. Transforming growth factor-β (TGF-β) is a pleiotropic cytokine which promotes breast cancer metastasis. ZBTB7A and TGF-β are important factors in tumor development. However, the association between ZBTB7A and TGF-β in breast cancer remains unknown. The results of the present study revealed that TGF-β1 induced the expression of ZBTB7A via the phosphoinositide 3-kinase-protein kinase B signaling pathway in human breast cancer cells, and ZBTB7A inhibited the expression of TGF-β1 through indirectly suppressing the promoter activity of TGF-β1. Furthermore, no significant correlation between the expression of ZBTB7A and TGF-β1 were identified in breast cancer tissues using tissue microarray assay and human cancer genomics analysis. These results have identified a negative feedback loop between ZBTB7A and TGF-β signaling, suggesting ZBTB7A as a potential modulator of breast cancer metastasis. Thus, the results of the present study suggested that ZBTB7A is a potential prognostic biomarker for breast cancer.
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spelling pubmed-55299332017-08-07 Negative feedback loop between ZBTB7A and TGF-β in breast cancer Shen, Yingying Cao, Renxian Liu, Wen Zhou, Yuqing Wu, Ying Tan, Jingjing Jin, Min Zhong, Jing Zhang, Qinghai Liu, Jianghua Zu, Xuyu Oncol Lett Articles Zinc finger and BTB domain containing 7A (ZBTB7A) is aberrantly expressed in breast cancer, but the involvement of ZBTB7A in breast cancer remains controversial. Transforming growth factor-β (TGF-β) is a pleiotropic cytokine which promotes breast cancer metastasis. ZBTB7A and TGF-β are important factors in tumor development. However, the association between ZBTB7A and TGF-β in breast cancer remains unknown. The results of the present study revealed that TGF-β1 induced the expression of ZBTB7A via the phosphoinositide 3-kinase-protein kinase B signaling pathway in human breast cancer cells, and ZBTB7A inhibited the expression of TGF-β1 through indirectly suppressing the promoter activity of TGF-β1. Furthermore, no significant correlation between the expression of ZBTB7A and TGF-β1 were identified in breast cancer tissues using tissue microarray assay and human cancer genomics analysis. These results have identified a negative feedback loop between ZBTB7A and TGF-β signaling, suggesting ZBTB7A as a potential modulator of breast cancer metastasis. Thus, the results of the present study suggested that ZBTB7A is a potential prognostic biomarker for breast cancer. D.A. Spandidos 2017-08 2017-06-01 /pmc/articles/PMC5529933/ /pubmed/28789356 http://dx.doi.org/10.3892/ol.2017.6291 Text en Copyright: © Shen et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Shen, Yingying
Cao, Renxian
Liu, Wen
Zhou, Yuqing
Wu, Ying
Tan, Jingjing
Jin, Min
Zhong, Jing
Zhang, Qinghai
Liu, Jianghua
Zu, Xuyu
Negative feedback loop between ZBTB7A and TGF-β in breast cancer
title Negative feedback loop between ZBTB7A and TGF-β in breast cancer
title_full Negative feedback loop between ZBTB7A and TGF-β in breast cancer
title_fullStr Negative feedback loop between ZBTB7A and TGF-β in breast cancer
title_full_unstemmed Negative feedback loop between ZBTB7A and TGF-β in breast cancer
title_short Negative feedback loop between ZBTB7A and TGF-β in breast cancer
title_sort negative feedback loop between zbtb7a and tgf-β in breast cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529933/
https://www.ncbi.nlm.nih.gov/pubmed/28789356
http://dx.doi.org/10.3892/ol.2017.6291
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