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Voltage-gated calcium channels: Novel targets for cancer therapy

Voltage-gated calcium channels (VGCCs) comprise five subtypes: The L-type; R-type; N-type; P/Q-type; and T-type, which are encoded by α(1) subunit genes. Calcium ion channels also have confirmed roles in cellular functions, including mitogenesis, proliferation, differentiation, apoptosis and metasta...

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Autores principales: Phan, Nam Nhut, Wang, Chih-Yang, Chen, Chien-Fu, Sun, Zhengda, Lai, Ming-Derg, Lin, Yen-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530219/
https://www.ncbi.nlm.nih.gov/pubmed/28781648
http://dx.doi.org/10.3892/ol.2017.6457
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author Phan, Nam Nhut
Wang, Chih-Yang
Chen, Chien-Fu
Sun, Zhengda
Lai, Ming-Derg
Lin, Yen-Chang
author_facet Phan, Nam Nhut
Wang, Chih-Yang
Chen, Chien-Fu
Sun, Zhengda
Lai, Ming-Derg
Lin, Yen-Chang
author_sort Phan, Nam Nhut
collection PubMed
description Voltage-gated calcium channels (VGCCs) comprise five subtypes: The L-type; R-type; N-type; P/Q-type; and T-type, which are encoded by α(1) subunit genes. Calcium ion channels also have confirmed roles in cellular functions, including mitogenesis, proliferation, differentiation, apoptosis and metastasis. An association between VGCCs, a reduction in proliferation and an increase in apoptosis in prostate cancer cells has also been reported. Therefore, in the present study, the online clinical database Oncomine was used to identify the alterations in the mRNA expression level of VGCCs in 19 cancer subtypes. Overall, VGCC family genes exhibited under-expression in numerous types of cancer, including brain, breast, kidney and lung cancers. Notably, the majority of VGCC family members (CACNA1C, CACNA1D, CACNA1A, CACNA1B, CACNA1E, CACNA1H and CACNA1I) exhibited low expression in brain tumors, with mRNA expression levels in the top 1–9% of downregulated gene rankings. A total of 5 VGCC family members (CACNA1A, CACNA1B, CACNA1E, CACNA1G and CACNA1I) were under-expressed in breast cancer, with a gene ranking in the top 1–10% of the low-expressed genes compared with normal tissue. In kidney and lung cancers, CACNA1S, CACNA1C, CACNA1D, CACNA1A and CACNA1H exhibited low expression, with gene rankings in the top 1–8% of downregulated genes. In conclusion, the present findings may contribute to the development of new cancer treatment approaches by identifying target genes involved in specific types of cancer.
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spelling pubmed-55302192017-08-04 Voltage-gated calcium channels: Novel targets for cancer therapy Phan, Nam Nhut Wang, Chih-Yang Chen, Chien-Fu Sun, Zhengda Lai, Ming-Derg Lin, Yen-Chang Oncol Lett Articles Voltage-gated calcium channels (VGCCs) comprise five subtypes: The L-type; R-type; N-type; P/Q-type; and T-type, which are encoded by α(1) subunit genes. Calcium ion channels also have confirmed roles in cellular functions, including mitogenesis, proliferation, differentiation, apoptosis and metastasis. An association between VGCCs, a reduction in proliferation and an increase in apoptosis in prostate cancer cells has also been reported. Therefore, in the present study, the online clinical database Oncomine was used to identify the alterations in the mRNA expression level of VGCCs in 19 cancer subtypes. Overall, VGCC family genes exhibited under-expression in numerous types of cancer, including brain, breast, kidney and lung cancers. Notably, the majority of VGCC family members (CACNA1C, CACNA1D, CACNA1A, CACNA1B, CACNA1E, CACNA1H and CACNA1I) exhibited low expression in brain tumors, with mRNA expression levels in the top 1–9% of downregulated gene rankings. A total of 5 VGCC family members (CACNA1A, CACNA1B, CACNA1E, CACNA1G and CACNA1I) were under-expressed in breast cancer, with a gene ranking in the top 1–10% of the low-expressed genes compared with normal tissue. In kidney and lung cancers, CACNA1S, CACNA1C, CACNA1D, CACNA1A and CACNA1H exhibited low expression, with gene rankings in the top 1–8% of downregulated genes. In conclusion, the present findings may contribute to the development of new cancer treatment approaches by identifying target genes involved in specific types of cancer. D.A. Spandidos 2017-08 2017-06-22 /pmc/articles/PMC5530219/ /pubmed/28781648 http://dx.doi.org/10.3892/ol.2017.6457 Text en Copyright: © Phan et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Phan, Nam Nhut
Wang, Chih-Yang
Chen, Chien-Fu
Sun, Zhengda
Lai, Ming-Derg
Lin, Yen-Chang
Voltage-gated calcium channels: Novel targets for cancer therapy
title Voltage-gated calcium channels: Novel targets for cancer therapy
title_full Voltage-gated calcium channels: Novel targets for cancer therapy
title_fullStr Voltage-gated calcium channels: Novel targets for cancer therapy
title_full_unstemmed Voltage-gated calcium channels: Novel targets for cancer therapy
title_short Voltage-gated calcium channels: Novel targets for cancer therapy
title_sort voltage-gated calcium channels: novel targets for cancer therapy
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530219/
https://www.ncbi.nlm.nih.gov/pubmed/28781648
http://dx.doi.org/10.3892/ol.2017.6457
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