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Voltage-gated calcium channels: Novel targets for cancer therapy
Voltage-gated calcium channels (VGCCs) comprise five subtypes: The L-type; R-type; N-type; P/Q-type; and T-type, which are encoded by α(1) subunit genes. Calcium ion channels also have confirmed roles in cellular functions, including mitogenesis, proliferation, differentiation, apoptosis and metasta...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530219/ https://www.ncbi.nlm.nih.gov/pubmed/28781648 http://dx.doi.org/10.3892/ol.2017.6457 |
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author | Phan, Nam Nhut Wang, Chih-Yang Chen, Chien-Fu Sun, Zhengda Lai, Ming-Derg Lin, Yen-Chang |
author_facet | Phan, Nam Nhut Wang, Chih-Yang Chen, Chien-Fu Sun, Zhengda Lai, Ming-Derg Lin, Yen-Chang |
author_sort | Phan, Nam Nhut |
collection | PubMed |
description | Voltage-gated calcium channels (VGCCs) comprise five subtypes: The L-type; R-type; N-type; P/Q-type; and T-type, which are encoded by α(1) subunit genes. Calcium ion channels also have confirmed roles in cellular functions, including mitogenesis, proliferation, differentiation, apoptosis and metastasis. An association between VGCCs, a reduction in proliferation and an increase in apoptosis in prostate cancer cells has also been reported. Therefore, in the present study, the online clinical database Oncomine was used to identify the alterations in the mRNA expression level of VGCCs in 19 cancer subtypes. Overall, VGCC family genes exhibited under-expression in numerous types of cancer, including brain, breast, kidney and lung cancers. Notably, the majority of VGCC family members (CACNA1C, CACNA1D, CACNA1A, CACNA1B, CACNA1E, CACNA1H and CACNA1I) exhibited low expression in brain tumors, with mRNA expression levels in the top 1–9% of downregulated gene rankings. A total of 5 VGCC family members (CACNA1A, CACNA1B, CACNA1E, CACNA1G and CACNA1I) were under-expressed in breast cancer, with a gene ranking in the top 1–10% of the low-expressed genes compared with normal tissue. In kidney and lung cancers, CACNA1S, CACNA1C, CACNA1D, CACNA1A and CACNA1H exhibited low expression, with gene rankings in the top 1–8% of downregulated genes. In conclusion, the present findings may contribute to the development of new cancer treatment approaches by identifying target genes involved in specific types of cancer. |
format | Online Article Text |
id | pubmed-5530219 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-55302192017-08-04 Voltage-gated calcium channels: Novel targets for cancer therapy Phan, Nam Nhut Wang, Chih-Yang Chen, Chien-Fu Sun, Zhengda Lai, Ming-Derg Lin, Yen-Chang Oncol Lett Articles Voltage-gated calcium channels (VGCCs) comprise five subtypes: The L-type; R-type; N-type; P/Q-type; and T-type, which are encoded by α(1) subunit genes. Calcium ion channels also have confirmed roles in cellular functions, including mitogenesis, proliferation, differentiation, apoptosis and metastasis. An association between VGCCs, a reduction in proliferation and an increase in apoptosis in prostate cancer cells has also been reported. Therefore, in the present study, the online clinical database Oncomine was used to identify the alterations in the mRNA expression level of VGCCs in 19 cancer subtypes. Overall, VGCC family genes exhibited under-expression in numerous types of cancer, including brain, breast, kidney and lung cancers. Notably, the majority of VGCC family members (CACNA1C, CACNA1D, CACNA1A, CACNA1B, CACNA1E, CACNA1H and CACNA1I) exhibited low expression in brain tumors, with mRNA expression levels in the top 1–9% of downregulated gene rankings. A total of 5 VGCC family members (CACNA1A, CACNA1B, CACNA1E, CACNA1G and CACNA1I) were under-expressed in breast cancer, with a gene ranking in the top 1–10% of the low-expressed genes compared with normal tissue. In kidney and lung cancers, CACNA1S, CACNA1C, CACNA1D, CACNA1A and CACNA1H exhibited low expression, with gene rankings in the top 1–8% of downregulated genes. In conclusion, the present findings may contribute to the development of new cancer treatment approaches by identifying target genes involved in specific types of cancer. D.A. Spandidos 2017-08 2017-06-22 /pmc/articles/PMC5530219/ /pubmed/28781648 http://dx.doi.org/10.3892/ol.2017.6457 Text en Copyright: © Phan et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Phan, Nam Nhut Wang, Chih-Yang Chen, Chien-Fu Sun, Zhengda Lai, Ming-Derg Lin, Yen-Chang Voltage-gated calcium channels: Novel targets for cancer therapy |
title | Voltage-gated calcium channels: Novel targets for cancer therapy |
title_full | Voltage-gated calcium channels: Novel targets for cancer therapy |
title_fullStr | Voltage-gated calcium channels: Novel targets for cancer therapy |
title_full_unstemmed | Voltage-gated calcium channels: Novel targets for cancer therapy |
title_short | Voltage-gated calcium channels: Novel targets for cancer therapy |
title_sort | voltage-gated calcium channels: novel targets for cancer therapy |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530219/ https://www.ncbi.nlm.nih.gov/pubmed/28781648 http://dx.doi.org/10.3892/ol.2017.6457 |
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