Cargando…
Treatment patterns and clinical characteristics of patients with type 2 diabetes mellitus according to body mass index: findings from an electronic medical records database
OBJECTIVE: This study evaluated relationships between glycaemic control, body mass index (BMI), comorbidities and pharmacological treatment in patients with type 2 diabetes mellitus (T2D). RESEARCH DESIGN AND METHODS: This was a retrospective, cross-sectional analysis of Quintiles electronic medical...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Open Diabetes Research & Care
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530246/ https://www.ncbi.nlm.nih.gov/pubmed/28761654 http://dx.doi.org/10.1136/bmjdrc-2016-000382 |
_version_ | 1783253240780947456 |
---|---|
author | Weng, Wayne Tian, Ye Kimball, Edward S. Kong, Sheldon X. Bouchard, Jonathan Hobbs, Todd M. Sakurada, Brian |
author_facet | Weng, Wayne Tian, Ye Kimball, Edward S. Kong, Sheldon X. Bouchard, Jonathan Hobbs, Todd M. Sakurada, Brian |
author_sort | Weng, Wayne |
collection | PubMed |
description | OBJECTIVE: This study evaluated relationships between glycaemic control, body mass index (BMI), comorbidities and pharmacological treatment in patients with type 2 diabetes mellitus (T2D). RESEARCH DESIGN AND METHODS: This was a retrospective, cross-sectional analysis of Quintiles electronic medical records research data (study period 1 October 2013–30 September 2014). Eligibility included age ≥18 years, T2D diagnosis, and at least one available BMI measurement. RESULTS: The study included 626 386 patients (mean age, 63.8 year; 51.3% female; 78.5% white; 62.6%, BMI ≥30 kg/m(2)). A1c data were available for 414 266 patients. The proportion of patients with good glycaemic control (A1c ≤6.5) decreased as BMI category increased, ranging from 40.1% of patients with BMI <30% to 30.1% of patients with BMI ≥40. The proportions of patients with poor glycaemic control (A1c >8% and A1c ≥9%) increased with increasing BMI category. Oral antidiabetic drugs (OAD) were the most frequently used (54.4% of patients with A1c values). Among patients using insulin-based therapy, 50% had an A1c ≥8% and 29% had an A1c ≥9% regardless of concomitant OAD or glucagon-like peptide 1 receptor agonist use. Among patients using three or more OADs, 34.3% and 16.1% had A1c values ≥8% and ≥9%, respectively. There was no common trend observed for changes in the proportion of patients with T2D-related comorbidities according to BMI category. The most notable trend was a 7.6% net increase in the percentage of patients with hypertension from BMI <30 to BMI ≥40. CONCLUSIONS: This large dataset provides evidence that roughly one out of four patients with T2D is not well controlled, and the prevalence of poor glycaemic control increases as BMI increases. |
format | Online Article Text |
id | pubmed-5530246 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BMJ Open Diabetes Research & Care |
record_format | MEDLINE/PubMed |
spelling | pubmed-55302462017-07-31 Treatment patterns and clinical characteristics of patients with type 2 diabetes mellitus according to body mass index: findings from an electronic medical records database Weng, Wayne Tian, Ye Kimball, Edward S. Kong, Sheldon X. Bouchard, Jonathan Hobbs, Todd M. Sakurada, Brian BMJ Open Diabetes Res Care Obesity Studies OBJECTIVE: This study evaluated relationships between glycaemic control, body mass index (BMI), comorbidities and pharmacological treatment in patients with type 2 diabetes mellitus (T2D). RESEARCH DESIGN AND METHODS: This was a retrospective, cross-sectional analysis of Quintiles electronic medical records research data (study period 1 October 2013–30 September 2014). Eligibility included age ≥18 years, T2D diagnosis, and at least one available BMI measurement. RESULTS: The study included 626 386 patients (mean age, 63.8 year; 51.3% female; 78.5% white; 62.6%, BMI ≥30 kg/m(2)). A1c data were available for 414 266 patients. The proportion of patients with good glycaemic control (A1c ≤6.5) decreased as BMI category increased, ranging from 40.1% of patients with BMI <30% to 30.1% of patients with BMI ≥40. The proportions of patients with poor glycaemic control (A1c >8% and A1c ≥9%) increased with increasing BMI category. Oral antidiabetic drugs (OAD) were the most frequently used (54.4% of patients with A1c values). Among patients using insulin-based therapy, 50% had an A1c ≥8% and 29% had an A1c ≥9% regardless of concomitant OAD or glucagon-like peptide 1 receptor agonist use. Among patients using three or more OADs, 34.3% and 16.1% had A1c values ≥8% and ≥9%, respectively. There was no common trend observed for changes in the proportion of patients with T2D-related comorbidities according to BMI category. The most notable trend was a 7.6% net increase in the percentage of patients with hypertension from BMI <30 to BMI ≥40. CONCLUSIONS: This large dataset provides evidence that roughly one out of four patients with T2D is not well controlled, and the prevalence of poor glycaemic control increases as BMI increases. BMJ Open Diabetes Research & Care 2017-05-27 /pmc/articles/PMC5530246/ /pubmed/28761654 http://dx.doi.org/10.1136/bmjdrc-2016-000382 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Obesity Studies Weng, Wayne Tian, Ye Kimball, Edward S. Kong, Sheldon X. Bouchard, Jonathan Hobbs, Todd M. Sakurada, Brian Treatment patterns and clinical characteristics of patients with type 2 diabetes mellitus according to body mass index: findings from an electronic medical records database |
title | Treatment patterns and clinical characteristics of patients with type 2 diabetes mellitus according to body mass index: findings from an electronic medical records database |
title_full | Treatment patterns and clinical characteristics of patients with type 2 diabetes mellitus according to body mass index: findings from an electronic medical records database |
title_fullStr | Treatment patterns and clinical characteristics of patients with type 2 diabetes mellitus according to body mass index: findings from an electronic medical records database |
title_full_unstemmed | Treatment patterns and clinical characteristics of patients with type 2 diabetes mellitus according to body mass index: findings from an electronic medical records database |
title_short | Treatment patterns and clinical characteristics of patients with type 2 diabetes mellitus according to body mass index: findings from an electronic medical records database |
title_sort | treatment patterns and clinical characteristics of patients with type 2 diabetes mellitus according to body mass index: findings from an electronic medical records database |
topic | Obesity Studies |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530246/ https://www.ncbi.nlm.nih.gov/pubmed/28761654 http://dx.doi.org/10.1136/bmjdrc-2016-000382 |
work_keys_str_mv | AT wengwayne treatmentpatternsandclinicalcharacteristicsofpatientswithtype2diabetesmellitusaccordingtobodymassindexfindingsfromanelectronicmedicalrecordsdatabase AT tianye treatmentpatternsandclinicalcharacteristicsofpatientswithtype2diabetesmellitusaccordingtobodymassindexfindingsfromanelectronicmedicalrecordsdatabase AT kimballedwards treatmentpatternsandclinicalcharacteristicsofpatientswithtype2diabetesmellitusaccordingtobodymassindexfindingsfromanelectronicmedicalrecordsdatabase AT kongsheldonx treatmentpatternsandclinicalcharacteristicsofpatientswithtype2diabetesmellitusaccordingtobodymassindexfindingsfromanelectronicmedicalrecordsdatabase AT bouchardjonathan treatmentpatternsandclinicalcharacteristicsofpatientswithtype2diabetesmellitusaccordingtobodymassindexfindingsfromanelectronicmedicalrecordsdatabase AT hobbstoddm treatmentpatternsandclinicalcharacteristicsofpatientswithtype2diabetesmellitusaccordingtobodymassindexfindingsfromanelectronicmedicalrecordsdatabase AT sakuradabrian treatmentpatternsandclinicalcharacteristicsofpatientswithtype2diabetesmellitusaccordingtobodymassindexfindingsfromanelectronicmedicalrecordsdatabase |