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Progression of Hepatic Adenoma to Carcinoma in Ogg1 Mutant Mice Induced by Phenobarbital

The carcinogenic potential of phenobarbital (PB) was assessed in a mouse line carrying a mutant Mmh allele of the Mmh/Ogg1 gene encoding the enzyme oxoguanine DNA glycosylase (Ogg1) responsible for the repair of 8-hydroxy-2′-deoxyguanosine (8-OHdG). Mmh homozygous mutant (Ogg1(−/−)) and wild-type (O...

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Detalles Bibliográficos
Autores principales:	Kakehashi, Anna, Ishii, Naomi, Okuno, Takahiro, Fujioka, Masaki, Gi, Min, Fukushima, Shoji, Wanibuchi, Hideki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530452/ https://www.ncbi.nlm.nih.gov/pubmed/28785378 http://dx.doi.org/10.1155/2017/8541064

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