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TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication

OBJECTIVE: We investigated the mutational landscape of mammalian target of rapamycin (mTOR) signalling cascade in hepatocellular carcinomas (HCCs) with chronic HBV background, aiming to evaluate and delineate mutation-dependent mechanism of mTOR hyperactivation in hepatocarcinogenesis. DESIGN: We pe...

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Detalles Bibliográficos
Autores principales:	Ho, Daniel W H, Chan, Lo K, Chiu, Yung T, Xu, Iris M J, Poon, Ronnie T P, Cheung, Tan T, Tang, Chung N, Tang, Victor W L, Lo, Irene L O, Lam, Polly W Y, Yau, Derek T W, Li, Miao X, Wong, Chun M, Ng, Irene O L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2017
Materias:	Hepatology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530480/ https://www.ncbi.nlm.nih.gov/pubmed/27974549 http://dx.doi.org/10.1136/gutjnl-2016-312734

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