Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids

The Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp. and Trypanosoma brucei and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heteroge...

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Detalles Bibliográficos
Autores principales: Damasceno, Jeziel D, Silva, Gabriel LA, Tschudi, Christian, Tosi, Luiz RO
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2017
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530550/
https://www.ncbi.nlm.nih.gov/pubmed/28767983
http://dx.doi.org/10.1590/0074-02760170054
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author Damasceno, Jeziel D
Silva, Gabriel LA
Tschudi, Christian
Tosi, Luiz RO
author_facet Damasceno, Jeziel D
Silva, Gabriel LA
Tschudi, Christian
Tosi, Luiz RO
author_sort Damasceno, Jeziel D
collection PubMed
description The Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp. and Trypanosoma brucei and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heterogeneous in size and partially polyadenylated. The levels of TERRA transcripts appear to be modulated through the life cycle in both trypanosomatids investigated, suggesting that TERRA play a stage-specific role in the life cycle of these early-branching eukaryotes.
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spelling pubmed-55305502017-08-02 Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids Damasceno, Jeziel D Silva, Gabriel LA Tschudi, Christian Tosi, Luiz RO Mem Inst Oswaldo Cruz Short Communication The Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp. and Trypanosoma brucei and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heterogeneous in size and partially polyadenylated. The levels of TERRA transcripts appear to be modulated through the life cycle in both trypanosomatids investigated, suggesting that TERRA play a stage-specific role in the life cycle of these early-branching eukaryotes. Instituto Oswaldo Cruz, Ministério da Saúde 2017-08 /pmc/articles/PMC5530550/ /pubmed/28767983 http://dx.doi.org/10.1590/0074-02760170054 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Damasceno, Jeziel D
Silva, Gabriel LA
Tschudi, Christian
Tosi, Luiz RO
Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids
title Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids
title_full Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids
title_fullStr Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids
title_full_unstemmed Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids
title_short Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids
title_sort evidence for regulated expression of telomeric repeat-containing rnas (terra) in parasitic trypanosomatids
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530550/
https://www.ncbi.nlm.nih.gov/pubmed/28767983
http://dx.doi.org/10.1590/0074-02760170054
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