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Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli

The formation of complex but highly organized neural circuits requires interactions between neurons and glia. During the assembly of the Drosophila olfactory circuit, 50 olfactory receptor neuron (ORN) classes and 50 projection neuron (PN) classes form synaptic connections in 50 glomerular compartme...

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Autores principales: Wu, Bing, Li, Jiefu, Chou, Ya-Hui, Luginbuhl, David, Luo, Liqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530699/
https://www.ncbi.nlm.nih.gov/pubmed/28674010
http://dx.doi.org/10.1073/pnas.1706533114
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author Wu, Bing
Li, Jiefu
Chou, Ya-Hui
Luginbuhl, David
Luo, Liqun
author_facet Wu, Bing
Li, Jiefu
Chou, Ya-Hui
Luginbuhl, David
Luo, Liqun
author_sort Wu, Bing
collection PubMed
description The formation of complex but highly organized neural circuits requires interactions between neurons and glia. During the assembly of the Drosophila olfactory circuit, 50 olfactory receptor neuron (ORN) classes and 50 projection neuron (PN) classes form synaptic connections in 50 glomerular compartments in the antennal lobe, each of which represents a discrete olfactory information-processing channel. Each compartment is separated from the adjacent compartments by membranous processes from ensheathing glia. Here we show that Thisbe, an FGF released from olfactory neurons, particularly from local interneurons, instructs ensheathing glia to wrap each glomerulus. The Heartless FGF receptor acts cell-autonomously in ensheathing glia to regulate process extension so as to insulate each neuropil compartment. Overexpressing Thisbe in ORNs or PNs causes overwrapping of the glomeruli their axons or dendrites target. Failure to establish the FGF-dependent glia structure disrupts precise ORN axon targeting and discrete glomerular formation.
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spelling pubmed-55306992017-07-31 Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli Wu, Bing Li, Jiefu Chou, Ya-Hui Luginbuhl, David Luo, Liqun Proc Natl Acad Sci U S A Biological Sciences The formation of complex but highly organized neural circuits requires interactions between neurons and glia. During the assembly of the Drosophila olfactory circuit, 50 olfactory receptor neuron (ORN) classes and 50 projection neuron (PN) classes form synaptic connections in 50 glomerular compartments in the antennal lobe, each of which represents a discrete olfactory information-processing channel. Each compartment is separated from the adjacent compartments by membranous processes from ensheathing glia. Here we show that Thisbe, an FGF released from olfactory neurons, particularly from local interneurons, instructs ensheathing glia to wrap each glomerulus. The Heartless FGF receptor acts cell-autonomously in ensheathing glia to regulate process extension so as to insulate each neuropil compartment. Overexpressing Thisbe in ORNs or PNs causes overwrapping of the glomeruli their axons or dendrites target. Failure to establish the FGF-dependent glia structure disrupts precise ORN axon targeting and discrete glomerular formation. National Academy of Sciences 2017-07-18 2017-07-03 /pmc/articles/PMC5530699/ /pubmed/28674010 http://dx.doi.org/10.1073/pnas.1706533114 Text en Freely available online through the PNAS open access option.
spellingShingle Biological Sciences
Wu, Bing
Li, Jiefu
Chou, Ya-Hui
Luginbuhl, David
Luo, Liqun
Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli
title Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli
title_full Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli
title_fullStr Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli
title_full_unstemmed Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli
title_short Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli
title_sort fibroblast growth factor signaling instructs ensheathing glia wrapping of drosophila olfactory glomeruli
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530699/
https://www.ncbi.nlm.nih.gov/pubmed/28674010
http://dx.doi.org/10.1073/pnas.1706533114
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