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Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli
The formation of complex but highly organized neural circuits requires interactions between neurons and glia. During the assembly of the Drosophila olfactory circuit, 50 olfactory receptor neuron (ORN) classes and 50 projection neuron (PN) classes form synaptic connections in 50 glomerular compartme...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530699/ https://www.ncbi.nlm.nih.gov/pubmed/28674010 http://dx.doi.org/10.1073/pnas.1706533114 |
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author | Wu, Bing Li, Jiefu Chou, Ya-Hui Luginbuhl, David Luo, Liqun |
author_facet | Wu, Bing Li, Jiefu Chou, Ya-Hui Luginbuhl, David Luo, Liqun |
author_sort | Wu, Bing |
collection | PubMed |
description | The formation of complex but highly organized neural circuits requires interactions between neurons and glia. During the assembly of the Drosophila olfactory circuit, 50 olfactory receptor neuron (ORN) classes and 50 projection neuron (PN) classes form synaptic connections in 50 glomerular compartments in the antennal lobe, each of which represents a discrete olfactory information-processing channel. Each compartment is separated from the adjacent compartments by membranous processes from ensheathing glia. Here we show that Thisbe, an FGF released from olfactory neurons, particularly from local interneurons, instructs ensheathing glia to wrap each glomerulus. The Heartless FGF receptor acts cell-autonomously in ensheathing glia to regulate process extension so as to insulate each neuropil compartment. Overexpressing Thisbe in ORNs or PNs causes overwrapping of the glomeruli their axons or dendrites target. Failure to establish the FGF-dependent glia structure disrupts precise ORN axon targeting and discrete glomerular formation. |
format | Online Article Text |
id | pubmed-5530699 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-55306992017-07-31 Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli Wu, Bing Li, Jiefu Chou, Ya-Hui Luginbuhl, David Luo, Liqun Proc Natl Acad Sci U S A Biological Sciences The formation of complex but highly organized neural circuits requires interactions between neurons and glia. During the assembly of the Drosophila olfactory circuit, 50 olfactory receptor neuron (ORN) classes and 50 projection neuron (PN) classes form synaptic connections in 50 glomerular compartments in the antennal lobe, each of which represents a discrete olfactory information-processing channel. Each compartment is separated from the adjacent compartments by membranous processes from ensheathing glia. Here we show that Thisbe, an FGF released from olfactory neurons, particularly from local interneurons, instructs ensheathing glia to wrap each glomerulus. The Heartless FGF receptor acts cell-autonomously in ensheathing glia to regulate process extension so as to insulate each neuropil compartment. Overexpressing Thisbe in ORNs or PNs causes overwrapping of the glomeruli their axons or dendrites target. Failure to establish the FGF-dependent glia structure disrupts precise ORN axon targeting and discrete glomerular formation. National Academy of Sciences 2017-07-18 2017-07-03 /pmc/articles/PMC5530699/ /pubmed/28674010 http://dx.doi.org/10.1073/pnas.1706533114 Text en Freely available online through the PNAS open access option. |
spellingShingle | Biological Sciences Wu, Bing Li, Jiefu Chou, Ya-Hui Luginbuhl, David Luo, Liqun Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli |
title | Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli |
title_full | Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli |
title_fullStr | Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli |
title_full_unstemmed | Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli |
title_short | Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli |
title_sort | fibroblast growth factor signaling instructs ensheathing glia wrapping of drosophila olfactory glomeruli |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530699/ https://www.ncbi.nlm.nih.gov/pubmed/28674010 http://dx.doi.org/10.1073/pnas.1706533114 |
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