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An improved preparation of phorbol from croton oil

Background: Croton oil is the only commercial source of the diterpenoid phorbol (1a), the starting material for the semi-synthesis of various diesters extensively used in biomedical research to investigate cell function and to evaluate in vivo anti-inflammatory activity. While efficient chemoselecti...

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Detalles Bibliográficos
Autores principales: Pagani, Alberto, Gaeta, Simone, Savchenko, Andrei I, Williams, Craig M, Appendino, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530722/
https://www.ncbi.nlm.nih.gov/pubmed/28781702
http://dx.doi.org/10.3762/bjoc.13.133