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Primary tumor location as a predictor of the benefit of palliative resection for colorectal cancer with unresectable metastasis

BACKGROUND: It is still under debate that whether stage IV colorectal cancer patients with unresectable metastasis can benefit from primary tumor resection, especially for asymptomatic colorectal cancer patients. Retrospective studies have shown controversial results concerning the benefit from surg...

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Autores principales: Zhang, Rong-xin, Ma, Wen-juan, Gu, Yu-ting, Zhang, Tian-qi, Huang, Zhi-mei, Lu, Zhen-hai, Gu, Yang-kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530936/
https://www.ncbi.nlm.nih.gov/pubmed/28750680
http://dx.doi.org/10.1186/s12957-017-1198-0
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author Zhang, Rong-xin
Ma, Wen-juan
Gu, Yu-ting
Zhang, Tian-qi
Huang, Zhi-mei
Lu, Zhen-hai
Gu, Yang-kui
author_facet Zhang, Rong-xin
Ma, Wen-juan
Gu, Yu-ting
Zhang, Tian-qi
Huang, Zhi-mei
Lu, Zhen-hai
Gu, Yang-kui
author_sort Zhang, Rong-xin
collection PubMed
description BACKGROUND: It is still under debate that whether stage IV colorectal cancer patients with unresectable metastasis can benefit from primary tumor resection, especially for asymptomatic colorectal cancer patients. Retrospective studies have shown controversial results concerning the benefit from surgery. This retrospective study aims to evaluate whether the site of primary tumor is a predictor of palliative resection in asymptomatic stage IV colorectal cancer patients. METHODS: One hundred ninety-four patients with unresectable metastatic colorectal cancer were selected from Sun Yat-sen University Cancer Center Database in the period between January 2007 and December 2013. All information was carefully reviewed and collected, including the treatment, age, sex, carcinoembryonic antigen, site of tumor, histology, cancer antigen 199, number of liver metastases, and largest diameter of liver metastasis. The univariate and multivariate analyses were used to detect the relationship between primary tumor resection and overall survival of unresectable stage IV colorectal cancer patients. RESULTS: One hundred twenty-five received palliative resection, and 69 received only chemotherapy. Multivariate analysis indicated that primary tumor site was one of the independent factors (RR 0.569, P = 0.007) that influenced overall survival. For left-side colon cancer patients, primary tumor resection prolonged the median overall survival time for 8 months (palliative resection vs. no palliative resection: 22 vs. 14 months, P = 0.009); however, for right-side colon cancer patients, palliative resection showed no benefit (12 vs. 10 months, P = 0.910). CONCLUSIONS: This study showed that left-side colon cancer patients might benefit from the primary tumor resection in terms of overall survival. This result should be further explored in a prospective study.
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spelling pubmed-55309362017-08-02 Primary tumor location as a predictor of the benefit of palliative resection for colorectal cancer with unresectable metastasis Zhang, Rong-xin Ma, Wen-juan Gu, Yu-ting Zhang, Tian-qi Huang, Zhi-mei Lu, Zhen-hai Gu, Yang-kui World J Surg Oncol Research BACKGROUND: It is still under debate that whether stage IV colorectal cancer patients with unresectable metastasis can benefit from primary tumor resection, especially for asymptomatic colorectal cancer patients. Retrospective studies have shown controversial results concerning the benefit from surgery. This retrospective study aims to evaluate whether the site of primary tumor is a predictor of palliative resection in asymptomatic stage IV colorectal cancer patients. METHODS: One hundred ninety-four patients with unresectable metastatic colorectal cancer were selected from Sun Yat-sen University Cancer Center Database in the period between January 2007 and December 2013. All information was carefully reviewed and collected, including the treatment, age, sex, carcinoembryonic antigen, site of tumor, histology, cancer antigen 199, number of liver metastases, and largest diameter of liver metastasis. The univariate and multivariate analyses were used to detect the relationship between primary tumor resection and overall survival of unresectable stage IV colorectal cancer patients. RESULTS: One hundred twenty-five received palliative resection, and 69 received only chemotherapy. Multivariate analysis indicated that primary tumor site was one of the independent factors (RR 0.569, P = 0.007) that influenced overall survival. For left-side colon cancer patients, primary tumor resection prolonged the median overall survival time for 8 months (palliative resection vs. no palliative resection: 22 vs. 14 months, P = 0.009); however, for right-side colon cancer patients, palliative resection showed no benefit (12 vs. 10 months, P = 0.910). CONCLUSIONS: This study showed that left-side colon cancer patients might benefit from the primary tumor resection in terms of overall survival. This result should be further explored in a prospective study. BioMed Central 2017-07-27 /pmc/articles/PMC5530936/ /pubmed/28750680 http://dx.doi.org/10.1186/s12957-017-1198-0 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Zhang, Rong-xin
Ma, Wen-juan
Gu, Yu-ting
Zhang, Tian-qi
Huang, Zhi-mei
Lu, Zhen-hai
Gu, Yang-kui
Primary tumor location as a predictor of the benefit of palliative resection for colorectal cancer with unresectable metastasis
title Primary tumor location as a predictor of the benefit of palliative resection for colorectal cancer with unresectable metastasis
title_full Primary tumor location as a predictor of the benefit of palliative resection for colorectal cancer with unresectable metastasis
title_fullStr Primary tumor location as a predictor of the benefit of palliative resection for colorectal cancer with unresectable metastasis
title_full_unstemmed Primary tumor location as a predictor of the benefit of palliative resection for colorectal cancer with unresectable metastasis
title_short Primary tumor location as a predictor of the benefit of palliative resection for colorectal cancer with unresectable metastasis
title_sort primary tumor location as a predictor of the benefit of palliative resection for colorectal cancer with unresectable metastasis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530936/
https://www.ncbi.nlm.nih.gov/pubmed/28750680
http://dx.doi.org/10.1186/s12957-017-1198-0
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