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Increased Aβ(42)-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer’s disease pathogenesis

BACKGROUND: The apolipoprotein E ε4 (APOE4) genotype is a prominent late-onset Alzheimer’s disease (AD) risk factor. ApoE4 disrupts memory function in rodents and may contribute to both plaque and tangle formation. METHODS: Coimmunoprecipitation and Western blot detection were used to determine: 1)...

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Detalles Bibliográficos
Autores principales:	Wang, Hoau-Yan, Trocmé-Thibierge, Caryn, Stucky, Andres, Shah, Sanket M., Kvasic, Jessica, Khan, Amber, Morain, Philippe, Guignot, Isabelle, Bouguen, Eva, Deschet, Karine, Pueyo, Maria, Mocaer, Elisabeth, Ousset, Pierre-Jean, Vellas, Bruno, Kiyasova, Vera
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530996/ https://www.ncbi.nlm.nih.gov/pubmed/28750690 http://dx.doi.org/10.1186/s13195-017-0280-8

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