From hybridomas to a robust microalgal-based production platform: molecular design of a diatom secreting monoclonal antibodies directed against the Marburg virus nucleoprotein

BACKGROUND: The ideal protein expression system should provide recombinant proteins in high quality and quantity involving low production costs only. However, especially for complex therapeutic proteins like monoclonal antibodies many challenges remain to meet this goal and up to now production of m...

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Detalles Bibliográficos
Autores principales: Hempel, Franziska, Maurer, Michael, Brockmann, Björn, Mayer, Christian, Biedenkopf, Nadine, Kelterbaum, Anne, Becker, Stephan, Maier, Uwe G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531009/
https://www.ncbi.nlm.nih.gov/pubmed/28750668
http://dx.doi.org/10.1186/s12934-017-0745-2

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