Cargando…

Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study

BACKGROUND: Animal studies suggest that bisphenol A (BPA) may perturb pubertal development in females. However, evidence from human studies is limited. METHODS: This was a cross-sectional study to investigate the association between BPA exposure and pubertal development in school-aged girls. A total...

Descripción completa

Detalles Bibliográficos
Autores principales: Miao, Maohua, Wang, Ziliang, Liu, Xiaoqin, Liang, Hong, Zhou, Zhijun, Tan, Hui, Yuan, Wei, Li, De-Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531012/
https://www.ncbi.nlm.nih.gov/pubmed/28750633
http://dx.doi.org/10.1186/s12940-017-0290-9
_version_ 1783253334645276672
author Miao, Maohua
Wang, Ziliang
Liu, Xiaoqin
Liang, Hong
Zhou, Zhijun
Tan, Hui
Yuan, Wei
Li, De-Kun
author_facet Miao, Maohua
Wang, Ziliang
Liu, Xiaoqin
Liang, Hong
Zhou, Zhijun
Tan, Hui
Yuan, Wei
Li, De-Kun
author_sort Miao, Maohua
collection PubMed
description BACKGROUND: Animal studies suggest that bisphenol A (BPA) may perturb pubertal development in females. However, evidence from human studies is limited. METHODS: This was a cross-sectional study to investigate the association between BPA exposure and pubertal development in school-aged girls. A total of 655 girls aged 9–18 years were selected from three schools in Shanghai, from May to June 2011. We collected one single spot urine sample from each girl. Urine BPA concentrations were measured by modified high-performance liquid chromatography and categorized according to LOD and the median of those above LOD. Pubertal development status was assessed by using Tanner staging, and age at menarche was collected as a milestone for mid-puberty. Modified Poisson regression was used to estimate adjusted prevalence ratios (PRs) and 95% confidence intervals (CIs). RESULTS: After adjustment for potential confounders, girls with detected BPA were more likely to have delayed menarche, a mid-puberty event, compared with girls with undetectable BPA; the prevalence ratios (PR) were 0.73 (0.56, 0.95) for those with moderate BPA(LOD-median) and 0.72 (0.52, 0.99) for those with high BPA(>median), respectively. Girls aged 9–12 years with detected BPA were more likely to have reached pubic hair stage 2, the indicator of pubarche; while among girls aged >15 years, those with detected BPA were less likely to have reached pubic hair stage 5, the late stage of pubic hair development. CONCLUSIONS: BPA exposure was associated with alterations in the timing of pubertal development. Results in the present study should be interpreted with caution because of its cross-sectional nature and the limited sample size in each age group.
format Online
Article
Text
id pubmed-5531012
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-55310122017-08-02 Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study Miao, Maohua Wang, Ziliang Liu, Xiaoqin Liang, Hong Zhou, Zhijun Tan, Hui Yuan, Wei Li, De-Kun Environ Health Research BACKGROUND: Animal studies suggest that bisphenol A (BPA) may perturb pubertal development in females. However, evidence from human studies is limited. METHODS: This was a cross-sectional study to investigate the association between BPA exposure and pubertal development in school-aged girls. A total of 655 girls aged 9–18 years were selected from three schools in Shanghai, from May to June 2011. We collected one single spot urine sample from each girl. Urine BPA concentrations were measured by modified high-performance liquid chromatography and categorized according to LOD and the median of those above LOD. Pubertal development status was assessed by using Tanner staging, and age at menarche was collected as a milestone for mid-puberty. Modified Poisson regression was used to estimate adjusted prevalence ratios (PRs) and 95% confidence intervals (CIs). RESULTS: After adjustment for potential confounders, girls with detected BPA were more likely to have delayed menarche, a mid-puberty event, compared with girls with undetectable BPA; the prevalence ratios (PR) were 0.73 (0.56, 0.95) for those with moderate BPA(LOD-median) and 0.72 (0.52, 0.99) for those with high BPA(>median), respectively. Girls aged 9–12 years with detected BPA were more likely to have reached pubic hair stage 2, the indicator of pubarche; while among girls aged >15 years, those with detected BPA were less likely to have reached pubic hair stage 5, the late stage of pubic hair development. CONCLUSIONS: BPA exposure was associated with alterations in the timing of pubertal development. Results in the present study should be interpreted with caution because of its cross-sectional nature and the limited sample size in each age group. BioMed Central 2017-07-27 /pmc/articles/PMC5531012/ /pubmed/28750633 http://dx.doi.org/10.1186/s12940-017-0290-9 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Miao, Maohua
Wang, Ziliang
Liu, Xiaoqin
Liang, Hong
Zhou, Zhijun
Tan, Hui
Yuan, Wei
Li, De-Kun
Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study
title Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study
title_full Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study
title_fullStr Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study
title_full_unstemmed Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study
title_short Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study
title_sort urinary bisphenol a and pubertal development in chinese school-aged girls: a cross-sectional study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531012/
https://www.ncbi.nlm.nih.gov/pubmed/28750633
http://dx.doi.org/10.1186/s12940-017-0290-9
work_keys_str_mv AT miaomaohua urinarybisphenolaandpubertaldevelopmentinchineseschoolagedgirlsacrosssectionalstudy
AT wangziliang urinarybisphenolaandpubertaldevelopmentinchineseschoolagedgirlsacrosssectionalstudy
AT liuxiaoqin urinarybisphenolaandpubertaldevelopmentinchineseschoolagedgirlsacrosssectionalstudy
AT lianghong urinarybisphenolaandpubertaldevelopmentinchineseschoolagedgirlsacrosssectionalstudy
AT zhouzhijun urinarybisphenolaandpubertaldevelopmentinchineseschoolagedgirlsacrosssectionalstudy
AT tanhui urinarybisphenolaandpubertaldevelopmentinchineseschoolagedgirlsacrosssectionalstudy
AT yuanwei urinarybisphenolaandpubertaldevelopmentinchineseschoolagedgirlsacrosssectionalstudy
AT lidekun urinarybisphenolaandpubertaldevelopmentinchineseschoolagedgirlsacrosssectionalstudy