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Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study
BACKGROUND: Animal studies suggest that bisphenol A (BPA) may perturb pubertal development in females. However, evidence from human studies is limited. METHODS: This was a cross-sectional study to investigate the association between BPA exposure and pubertal development in school-aged girls. A total...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531012/ https://www.ncbi.nlm.nih.gov/pubmed/28750633 http://dx.doi.org/10.1186/s12940-017-0290-9 |
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author | Miao, Maohua Wang, Ziliang Liu, Xiaoqin Liang, Hong Zhou, Zhijun Tan, Hui Yuan, Wei Li, De-Kun |
author_facet | Miao, Maohua Wang, Ziliang Liu, Xiaoqin Liang, Hong Zhou, Zhijun Tan, Hui Yuan, Wei Li, De-Kun |
author_sort | Miao, Maohua |
collection | PubMed |
description | BACKGROUND: Animal studies suggest that bisphenol A (BPA) may perturb pubertal development in females. However, evidence from human studies is limited. METHODS: This was a cross-sectional study to investigate the association between BPA exposure and pubertal development in school-aged girls. A total of 655 girls aged 9–18 years were selected from three schools in Shanghai, from May to June 2011. We collected one single spot urine sample from each girl. Urine BPA concentrations were measured by modified high-performance liquid chromatography and categorized according to LOD and the median of those above LOD. Pubertal development status was assessed by using Tanner staging, and age at menarche was collected as a milestone for mid-puberty. Modified Poisson regression was used to estimate adjusted prevalence ratios (PRs) and 95% confidence intervals (CIs). RESULTS: After adjustment for potential confounders, girls with detected BPA were more likely to have delayed menarche, a mid-puberty event, compared with girls with undetectable BPA; the prevalence ratios (PR) were 0.73 (0.56, 0.95) for those with moderate BPA(LOD-median) and 0.72 (0.52, 0.99) for those with high BPA(>median), respectively. Girls aged 9–12 years with detected BPA were more likely to have reached pubic hair stage 2, the indicator of pubarche; while among girls aged >15 years, those with detected BPA were less likely to have reached pubic hair stage 5, the late stage of pubic hair development. CONCLUSIONS: BPA exposure was associated with alterations in the timing of pubertal development. Results in the present study should be interpreted with caution because of its cross-sectional nature and the limited sample size in each age group. |
format | Online Article Text |
id | pubmed-5531012 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-55310122017-08-02 Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study Miao, Maohua Wang, Ziliang Liu, Xiaoqin Liang, Hong Zhou, Zhijun Tan, Hui Yuan, Wei Li, De-Kun Environ Health Research BACKGROUND: Animal studies suggest that bisphenol A (BPA) may perturb pubertal development in females. However, evidence from human studies is limited. METHODS: This was a cross-sectional study to investigate the association between BPA exposure and pubertal development in school-aged girls. A total of 655 girls aged 9–18 years were selected from three schools in Shanghai, from May to June 2011. We collected one single spot urine sample from each girl. Urine BPA concentrations were measured by modified high-performance liquid chromatography and categorized according to LOD and the median of those above LOD. Pubertal development status was assessed by using Tanner staging, and age at menarche was collected as a milestone for mid-puberty. Modified Poisson regression was used to estimate adjusted prevalence ratios (PRs) and 95% confidence intervals (CIs). RESULTS: After adjustment for potential confounders, girls with detected BPA were more likely to have delayed menarche, a mid-puberty event, compared with girls with undetectable BPA; the prevalence ratios (PR) were 0.73 (0.56, 0.95) for those with moderate BPA(LOD-median) and 0.72 (0.52, 0.99) for those with high BPA(>median), respectively. Girls aged 9–12 years with detected BPA were more likely to have reached pubic hair stage 2, the indicator of pubarche; while among girls aged >15 years, those with detected BPA were less likely to have reached pubic hair stage 5, the late stage of pubic hair development. CONCLUSIONS: BPA exposure was associated with alterations in the timing of pubertal development. Results in the present study should be interpreted with caution because of its cross-sectional nature and the limited sample size in each age group. BioMed Central 2017-07-27 /pmc/articles/PMC5531012/ /pubmed/28750633 http://dx.doi.org/10.1186/s12940-017-0290-9 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Miao, Maohua Wang, Ziliang Liu, Xiaoqin Liang, Hong Zhou, Zhijun Tan, Hui Yuan, Wei Li, De-Kun Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study |
title | Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study |
title_full | Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study |
title_fullStr | Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study |
title_full_unstemmed | Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study |
title_short | Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study |
title_sort | urinary bisphenol a and pubertal development in chinese school-aged girls: a cross-sectional study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531012/ https://www.ncbi.nlm.nih.gov/pubmed/28750633 http://dx.doi.org/10.1186/s12940-017-0290-9 |
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