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Unraveling Neisseria meningitidis pathogenesis: from functional genomics to experimental models
Neisseria meningitidis is a harmless commensal bacterium finely adapted to humans. Unfortunately, under “privileged” conditions, it adopts a “devious” lifestyle leading to uncontrolled behavior characterized by the unleashing of molecular weapons causing potentially lethal disease such as sepsis and...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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F1000Research
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531161/ https://www.ncbi.nlm.nih.gov/pubmed/28781769 http://dx.doi.org/10.12688/f1000research.11279.1 |
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author | Soriani, Marco |
author_facet | Soriani, Marco |
author_sort | Soriani, Marco |
collection | PubMed |
description | Neisseria meningitidis is a harmless commensal bacterium finely adapted to humans. Unfortunately, under “privileged” conditions, it adopts a “devious” lifestyle leading to uncontrolled behavior characterized by the unleashing of molecular weapons causing potentially lethal disease such as sepsis and acute meningitis. Indeed, despite the lack of a classic repertoire of virulence genes in N. meningitidis separating commensal from invasive strains, molecular epidemiology and functional genomics studies suggest that carriage and invasive strains belong to genetically distinct populations characterized by an exclusive pathogenic potential. In the last few years, “omics” technologies have helped scientists to unwrap the framework drawn by N. meningitidis during different stages of colonization and disease. However, this scenario is still incomplete and would benefit from the implementation of physiological tissue models for the reproduction of mucosal and systemic interactions in vitro. These emerging technologies supported by recent advances in the world of stem cell biology hold the promise for a further understanding of N. meningitidis pathogenesis. |
format | Online Article Text |
id | pubmed-5531161 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | F1000Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-55311612017-08-04 Unraveling Neisseria meningitidis pathogenesis: from functional genomics to experimental models Soriani, Marco F1000Res Review Neisseria meningitidis is a harmless commensal bacterium finely adapted to humans. Unfortunately, under “privileged” conditions, it adopts a “devious” lifestyle leading to uncontrolled behavior characterized by the unleashing of molecular weapons causing potentially lethal disease such as sepsis and acute meningitis. Indeed, despite the lack of a classic repertoire of virulence genes in N. meningitidis separating commensal from invasive strains, molecular epidemiology and functional genomics studies suggest that carriage and invasive strains belong to genetically distinct populations characterized by an exclusive pathogenic potential. In the last few years, “omics” technologies have helped scientists to unwrap the framework drawn by N. meningitidis during different stages of colonization and disease. However, this scenario is still incomplete and would benefit from the implementation of physiological tissue models for the reproduction of mucosal and systemic interactions in vitro. These emerging technologies supported by recent advances in the world of stem cell biology hold the promise for a further understanding of N. meningitidis pathogenesis. F1000Research 2017-07-26 /pmc/articles/PMC5531161/ /pubmed/28781769 http://dx.doi.org/10.12688/f1000research.11279.1 Text en Copyright: © 2017 Soriani M http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Soriani, Marco Unraveling Neisseria meningitidis pathogenesis: from functional genomics to experimental models |
title | Unraveling
Neisseria meningitidis pathogenesis: from functional genomics to experimental models |
title_full | Unraveling
Neisseria meningitidis pathogenesis: from functional genomics to experimental models |
title_fullStr | Unraveling
Neisseria meningitidis pathogenesis: from functional genomics to experimental models |
title_full_unstemmed | Unraveling
Neisseria meningitidis pathogenesis: from functional genomics to experimental models |
title_short | Unraveling
Neisseria meningitidis pathogenesis: from functional genomics to experimental models |
title_sort | unraveling
neisseria meningitidis pathogenesis: from functional genomics to experimental models |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531161/ https://www.ncbi.nlm.nih.gov/pubmed/28781769 http://dx.doi.org/10.12688/f1000research.11279.1 |
work_keys_str_mv | AT sorianimarco unravelingneisseriameningitidispathogenesisfromfunctionalgenomicstoexperimentalmodels |