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Unraveling Neisseria meningitidis pathogenesis: from functional genomics to experimental models

Neisseria meningitidis is a harmless commensal bacterium finely adapted to humans. Unfortunately, under “privileged” conditions, it adopts a “devious” lifestyle leading to uncontrolled behavior characterized by the unleashing of molecular weapons causing potentially lethal disease such as sepsis and...

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Detalles Bibliográficos
Autor principal: Soriani, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531161/
https://www.ncbi.nlm.nih.gov/pubmed/28781769
http://dx.doi.org/10.12688/f1000research.11279.1
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author Soriani, Marco
author_facet Soriani, Marco
author_sort Soriani, Marco
collection PubMed
description Neisseria meningitidis is a harmless commensal bacterium finely adapted to humans. Unfortunately, under “privileged” conditions, it adopts a “devious” lifestyle leading to uncontrolled behavior characterized by the unleashing of molecular weapons causing potentially lethal disease such as sepsis and acute meningitis. Indeed, despite the lack of a classic repertoire of virulence genes in N. meningitidis separating commensal from invasive strains, molecular epidemiology and functional genomics studies suggest that carriage and invasive strains belong to genetically distinct populations characterized by an exclusive pathogenic potential. In the last few years, “omics” technologies have helped scientists to unwrap the framework drawn by N. meningitidis during different stages of colonization and disease. However, this scenario is still incomplete and would benefit from the implementation of physiological tissue models for the reproduction of mucosal and systemic interactions in vitro. These emerging technologies supported by recent advances in the world of stem cell biology hold the promise for a further understanding of N. meningitidis pathogenesis.
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spelling pubmed-55311612017-08-04 Unraveling Neisseria meningitidis pathogenesis: from functional genomics to experimental models Soriani, Marco F1000Res Review Neisseria meningitidis is a harmless commensal bacterium finely adapted to humans. Unfortunately, under “privileged” conditions, it adopts a “devious” lifestyle leading to uncontrolled behavior characterized by the unleashing of molecular weapons causing potentially lethal disease such as sepsis and acute meningitis. Indeed, despite the lack of a classic repertoire of virulence genes in N. meningitidis separating commensal from invasive strains, molecular epidemiology and functional genomics studies suggest that carriage and invasive strains belong to genetically distinct populations characterized by an exclusive pathogenic potential. In the last few years, “omics” technologies have helped scientists to unwrap the framework drawn by N. meningitidis during different stages of colonization and disease. However, this scenario is still incomplete and would benefit from the implementation of physiological tissue models for the reproduction of mucosal and systemic interactions in vitro. These emerging technologies supported by recent advances in the world of stem cell biology hold the promise for a further understanding of N. meningitidis pathogenesis. F1000Research 2017-07-26 /pmc/articles/PMC5531161/ /pubmed/28781769 http://dx.doi.org/10.12688/f1000research.11279.1 Text en Copyright: © 2017 Soriani M http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Soriani, Marco
Unraveling Neisseria meningitidis pathogenesis: from functional genomics to experimental models
title Unraveling Neisseria meningitidis pathogenesis: from functional genomics to experimental models
title_full Unraveling Neisseria meningitidis pathogenesis: from functional genomics to experimental models
title_fullStr Unraveling Neisseria meningitidis pathogenesis: from functional genomics to experimental models
title_full_unstemmed Unraveling Neisseria meningitidis pathogenesis: from functional genomics to experimental models
title_short Unraveling Neisseria meningitidis pathogenesis: from functional genomics to experimental models
title_sort unraveling neisseria meningitidis pathogenesis: from functional genomics to experimental models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531161/
https://www.ncbi.nlm.nih.gov/pubmed/28781769
http://dx.doi.org/10.12688/f1000research.11279.1
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