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Breathing–swallowing discoordination is associated with frequent exacerbations of COPD
INTRODUCTION: Impaired coordination between breathing and swallowing (breathing–swallowing discoordination) may be a significant risk factor for the exacerbation of chronic obstructive pulmonary disease (COPD). We examined breathing–swallowing discoordination in patients with COPD using a non-invasi...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531308/ https://www.ncbi.nlm.nih.gov/pubmed/28883930 http://dx.doi.org/10.1136/bmjresp-2017-000202 |
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author | Nagami, Shinsuke Oku, Yoshitaka Yagi, Naomi Sato, Susumu Uozumi, Ryuji Morita, Satoshi Yamagata, Yoshie Kayashita, Jun Tanimura, Kazuya Sato, Atsuyasu Takahashi, Ryosuke Muro, Shigeo |
author_facet | Nagami, Shinsuke Oku, Yoshitaka Yagi, Naomi Sato, Susumu Uozumi, Ryuji Morita, Satoshi Yamagata, Yoshie Kayashita, Jun Tanimura, Kazuya Sato, Atsuyasu Takahashi, Ryosuke Muro, Shigeo |
author_sort | Nagami, Shinsuke |
collection | PubMed |
description | INTRODUCTION: Impaired coordination between breathing and swallowing (breathing–swallowing discoordination) may be a significant risk factor for the exacerbation of chronic obstructive pulmonary disease (COPD). We examined breathing–swallowing discoordination in patients with COPD using a non-invasive and quantitative technique and determined its association with COPD exacerbation. METHODS: We recruited 65 stable outpatients with COPD who were enrolled in our prospective observational cohort study and did not manifest an apparent swallowing disorder. COPD exacerbation was monitored for 1 year before and 1 year after recruitment. Swallowing during inspiration (the I-SW pattern) and swallowing immediately followed by inspiration (the SW-I pattern) were identified. RESULTS: The mean frequency of the I-SW and/or SW-I patterns (I-SW/SW-I rate) was 21.5%±25.5%. During the 2-year observation period, 48 exacerbation incidents (25 patients) were identified. The I-SW/SW-I rate was significantly associated with the frequency of exacerbation. During the year following recruitment, patients with a higher I-SW/SW-I frequency using thicker test foods exhibited a significantly higher probability of future exacerbations (p=0.002, log-rank test). CONCLUSIONS: Breathing–swallowing discoordination is strongly associated with frequent exacerbations of COPD. Strategies that identify and improve breathing–swallowing coordination may be a new therapeutic treatment for patients with COPD. |
format | Online Article Text |
id | pubmed-5531308 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-55313082017-09-07 Breathing–swallowing discoordination is associated with frequent exacerbations of COPD Nagami, Shinsuke Oku, Yoshitaka Yagi, Naomi Sato, Susumu Uozumi, Ryuji Morita, Satoshi Yamagata, Yoshie Kayashita, Jun Tanimura, Kazuya Sato, Atsuyasu Takahashi, Ryosuke Muro, Shigeo BMJ Open Respir Res Chronic Obstructive Pulmonary Disease INTRODUCTION: Impaired coordination between breathing and swallowing (breathing–swallowing discoordination) may be a significant risk factor for the exacerbation of chronic obstructive pulmonary disease (COPD). We examined breathing–swallowing discoordination in patients with COPD using a non-invasive and quantitative technique and determined its association with COPD exacerbation. METHODS: We recruited 65 stable outpatients with COPD who were enrolled in our prospective observational cohort study and did not manifest an apparent swallowing disorder. COPD exacerbation was monitored for 1 year before and 1 year after recruitment. Swallowing during inspiration (the I-SW pattern) and swallowing immediately followed by inspiration (the SW-I pattern) were identified. RESULTS: The mean frequency of the I-SW and/or SW-I patterns (I-SW/SW-I rate) was 21.5%±25.5%. During the 2-year observation period, 48 exacerbation incidents (25 patients) were identified. The I-SW/SW-I rate was significantly associated with the frequency of exacerbation. During the year following recruitment, patients with a higher I-SW/SW-I frequency using thicker test foods exhibited a significantly higher probability of future exacerbations (p=0.002, log-rank test). CONCLUSIONS: Breathing–swallowing discoordination is strongly associated with frequent exacerbations of COPD. Strategies that identify and improve breathing–swallowing coordination may be a new therapeutic treatment for patients with COPD. BMJ Publishing Group 2017-06-04 /pmc/articles/PMC5531308/ /pubmed/28883930 http://dx.doi.org/10.1136/bmjresp-2017-000202 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Chronic Obstructive Pulmonary Disease Nagami, Shinsuke Oku, Yoshitaka Yagi, Naomi Sato, Susumu Uozumi, Ryuji Morita, Satoshi Yamagata, Yoshie Kayashita, Jun Tanimura, Kazuya Sato, Atsuyasu Takahashi, Ryosuke Muro, Shigeo Breathing–swallowing discoordination is associated with frequent exacerbations of COPD |
title | Breathing–swallowing discoordination is associated with frequent exacerbations of COPD |
title_full | Breathing–swallowing discoordination is associated with frequent exacerbations of COPD |
title_fullStr | Breathing–swallowing discoordination is associated with frequent exacerbations of COPD |
title_full_unstemmed | Breathing–swallowing discoordination is associated with frequent exacerbations of COPD |
title_short | Breathing–swallowing discoordination is associated with frequent exacerbations of COPD |
title_sort | breathing–swallowing discoordination is associated with frequent exacerbations of copd |
topic | Chronic Obstructive Pulmonary Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531308/ https://www.ncbi.nlm.nih.gov/pubmed/28883930 http://dx.doi.org/10.1136/bmjresp-2017-000202 |
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