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HIV drug resistance in HIV positive individuals under antiretroviral treatment in Shandong Province, China

The efficacy of antiretroviral drugs is limited by the development of drug resistance. Therefore, it is important to examine HIV drug resistance following the nationwide implementation of drug resistance testing in China since 2009. We conducted drug resistance testing in patients who were already o...

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Autores principales: Lin, Bin, Sun, Xiaoguang, Su, Shengli, Lv, Cuixia, Zhang, Xiaofei, Lin, Lin, Wang, Rui, Fu, Jihua, Kang, Dianmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531464/
https://www.ncbi.nlm.nih.gov/pubmed/28750025
http://dx.doi.org/10.1371/journal.pone.0181997
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author Lin, Bin
Sun, Xiaoguang
Su, Shengli
Lv, Cuixia
Zhang, Xiaofei
Lin, Lin
Wang, Rui
Fu, Jihua
Kang, Dianmin
author_facet Lin, Bin
Sun, Xiaoguang
Su, Shengli
Lv, Cuixia
Zhang, Xiaofei
Lin, Lin
Wang, Rui
Fu, Jihua
Kang, Dianmin
author_sort Lin, Bin
collection PubMed
description The efficacy of antiretroviral drugs is limited by the development of drug resistance. Therefore, it is important to examine HIV drug resistance following the nationwide implementation of drug resistance testing in China since 2009. We conducted drug resistance testing in patients who were already on or new to HIV antiretroviral therapy (ART) in Shandong Province, China, from 2011 to 2013, and grouped them based on the presence or absence of drug resistance to determine the effects of age, gender, ethnicity, marital status, educational level, route of transmission and treatment status on drug resistance. We then examined levels of drug resistance the following year. The drug resistance rates of HIV patients on ART in Shandong from 2011 to 2013 were 3.45% (21/608), 3.38% (31/916), and 4.29% (54/1259), per year, respectively. M184V was the most frequently found point mutation, conferring resistance to the nucleoside reverse transcriptase inhibitor, while Y181C, G190A, K103N and V179D/E/F were the most frequent point mutations conferring resistance to the non-nucleoside reverse transcriptase inhibitor. In addition, the protease inhibitor drug resistance mutations I54V and V82A were identified for the first time in Shandong Province. Primary resistance accounts for 20% of the impact factors for drug resistance. Furthermore, it was found that educational level and treatment regimen were high-risk factors for drug resistance in 2011 (P<0.05), while treatment regimen was a high risk factor for drug resistance in 2012 and 2013 (P<0.05). Among the 106 drug-resistant patients, 77 received immediate adjustment of treatment regimen following testing, and 69 (89.6%) showed a reduction in drug resistance the following year. HIV drug resistance has a low prevalence in Shandong Province. However, patients on second line ART regimens and those with low educational level need continuous monitoring. Active drug resistance testing can effectively prevent the development of drug resistance.
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spelling pubmed-55314642017-08-07 HIV drug resistance in HIV positive individuals under antiretroviral treatment in Shandong Province, China Lin, Bin Sun, Xiaoguang Su, Shengli Lv, Cuixia Zhang, Xiaofei Lin, Lin Wang, Rui Fu, Jihua Kang, Dianmin PLoS One Research Article The efficacy of antiretroviral drugs is limited by the development of drug resistance. Therefore, it is important to examine HIV drug resistance following the nationwide implementation of drug resistance testing in China since 2009. We conducted drug resistance testing in patients who were already on or new to HIV antiretroviral therapy (ART) in Shandong Province, China, from 2011 to 2013, and grouped them based on the presence or absence of drug resistance to determine the effects of age, gender, ethnicity, marital status, educational level, route of transmission and treatment status on drug resistance. We then examined levels of drug resistance the following year. The drug resistance rates of HIV patients on ART in Shandong from 2011 to 2013 were 3.45% (21/608), 3.38% (31/916), and 4.29% (54/1259), per year, respectively. M184V was the most frequently found point mutation, conferring resistance to the nucleoside reverse transcriptase inhibitor, while Y181C, G190A, K103N and V179D/E/F were the most frequent point mutations conferring resistance to the non-nucleoside reverse transcriptase inhibitor. In addition, the protease inhibitor drug resistance mutations I54V and V82A were identified for the first time in Shandong Province. Primary resistance accounts for 20% of the impact factors for drug resistance. Furthermore, it was found that educational level and treatment regimen were high-risk factors for drug resistance in 2011 (P<0.05), while treatment regimen was a high risk factor for drug resistance in 2012 and 2013 (P<0.05). Among the 106 drug-resistant patients, 77 received immediate adjustment of treatment regimen following testing, and 69 (89.6%) showed a reduction in drug resistance the following year. HIV drug resistance has a low prevalence in Shandong Province. However, patients on second line ART regimens and those with low educational level need continuous monitoring. Active drug resistance testing can effectively prevent the development of drug resistance. Public Library of Science 2017-07-27 /pmc/articles/PMC5531464/ /pubmed/28750025 http://dx.doi.org/10.1371/journal.pone.0181997 Text en © 2017 Lin et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lin, Bin
Sun, Xiaoguang
Su, Shengli
Lv, Cuixia
Zhang, Xiaofei
Lin, Lin
Wang, Rui
Fu, Jihua
Kang, Dianmin
HIV drug resistance in HIV positive individuals under antiretroviral treatment in Shandong Province, China
title HIV drug resistance in HIV positive individuals under antiretroviral treatment in Shandong Province, China
title_full HIV drug resistance in HIV positive individuals under antiretroviral treatment in Shandong Province, China
title_fullStr HIV drug resistance in HIV positive individuals under antiretroviral treatment in Shandong Province, China
title_full_unstemmed HIV drug resistance in HIV positive individuals under antiretroviral treatment in Shandong Province, China
title_short HIV drug resistance in HIV positive individuals under antiretroviral treatment in Shandong Province, China
title_sort hiv drug resistance in hiv positive individuals under antiretroviral treatment in shandong province, china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531464/
https://www.ncbi.nlm.nih.gov/pubmed/28750025
http://dx.doi.org/10.1371/journal.pone.0181997
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