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From grid cells to place cells with realistic field sizes
While grid cells in the medial entorhinal cortex (MEC) of rodents have multiple, regularly arranged firing fields, place cells in the cornu ammonis (CA) regions of the hippocampus mostly have single spatial firing fields. Since there are extensive projections from MEC to the CA regions, many models...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531553/ https://www.ncbi.nlm.nih.gov/pubmed/28750005 http://dx.doi.org/10.1371/journal.pone.0181618 |
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author | Neher, Torsten Azizi, Amir Hossein Cheng, Sen |
author_facet | Neher, Torsten Azizi, Amir Hossein Cheng, Sen |
author_sort | Neher, Torsten |
collection | PubMed |
description | While grid cells in the medial entorhinal cortex (MEC) of rodents have multiple, regularly arranged firing fields, place cells in the cornu ammonis (CA) regions of the hippocampus mostly have single spatial firing fields. Since there are extensive projections from MEC to the CA regions, many models have suggested that a feedforward network can transform grid cell firing into robust place cell firing. However, these models generate place fields that are consistently too small compared to those recorded in experiments. Here, we argue that it is implausible that grid cell activity alone can be transformed into place cells with robust place fields of realistic size in a feedforward network. We propose two solutions to this problem. Firstly, weakly spatially modulated cells, which are abundant throughout EC, provide input to downstream place cells along with grid cells. This simple model reproduces many place cell characteristics as well as results from lesion studies. Secondly, the recurrent connections between place cells in the CA3 network generate robust and realistic place fields. Both mechanisms could work in parallel in the hippocampal formation and this redundancy might account for the robustness of place cell responses to a range of disruptions of the hippocampal circuitry. |
format | Online Article Text |
id | pubmed-5531553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-55315532017-08-07 From grid cells to place cells with realistic field sizes Neher, Torsten Azizi, Amir Hossein Cheng, Sen PLoS One Research Article While grid cells in the medial entorhinal cortex (MEC) of rodents have multiple, regularly arranged firing fields, place cells in the cornu ammonis (CA) regions of the hippocampus mostly have single spatial firing fields. Since there are extensive projections from MEC to the CA regions, many models have suggested that a feedforward network can transform grid cell firing into robust place cell firing. However, these models generate place fields that are consistently too small compared to those recorded in experiments. Here, we argue that it is implausible that grid cell activity alone can be transformed into place cells with robust place fields of realistic size in a feedforward network. We propose two solutions to this problem. Firstly, weakly spatially modulated cells, which are abundant throughout EC, provide input to downstream place cells along with grid cells. This simple model reproduces many place cell characteristics as well as results from lesion studies. Secondly, the recurrent connections between place cells in the CA3 network generate robust and realistic place fields. Both mechanisms could work in parallel in the hippocampal formation and this redundancy might account for the robustness of place cell responses to a range of disruptions of the hippocampal circuitry. Public Library of Science 2017-07-27 /pmc/articles/PMC5531553/ /pubmed/28750005 http://dx.doi.org/10.1371/journal.pone.0181618 Text en © 2017 Neher et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Neher, Torsten Azizi, Amir Hossein Cheng, Sen From grid cells to place cells with realistic field sizes |
title | From grid cells to place cells with realistic field sizes |
title_full | From grid cells to place cells with realistic field sizes |
title_fullStr | From grid cells to place cells with realistic field sizes |
title_full_unstemmed | From grid cells to place cells with realistic field sizes |
title_short | From grid cells to place cells with realistic field sizes |
title_sort | from grid cells to place cells with realistic field sizes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531553/ https://www.ncbi.nlm.nih.gov/pubmed/28750005 http://dx.doi.org/10.1371/journal.pone.0181618 |
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