Crystal structure and kinetic analysis of the class B3 di-zinc metallo-β-lactamase LRA-12 from an Alaskan soil metagenome

We analyzed the kinetic properties of the metagenomic class B3 β-lactamase LRA-12, and determined its crystallographic structure in order to compare it with prevalent metallo-β-lactamases (MBLs) associated with clinical pathogens. We showed that LRA-12 confers extended-spectrum resistance on E. coli...

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Detalles Bibliográficos
Autores principales: Rodríguez, María Margarita, Herman, Raphaël, Ghiglione, Barbara, Kerff, Frédéric, D’Amico González, Gabriela, Bouillenne, Fabrice, Galleni, Moreno, Handelsman, Jo, Charlier, Paulette, Gutkind, Gabriel, Sauvage, Eric, Power, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531557/
https://www.ncbi.nlm.nih.gov/pubmed/28750094
http://dx.doi.org/10.1371/journal.pone.0182043

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