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Enhanced generation of iPSCs from older adult human cells by a synthetic five-factor self-replicative RNA
We previously devised a polycistronic, synthetic self-replicating RNA (srRNA) to generate human induced Pluripotent Stem Cells (iPSCs) that simultaneously expresses four reprogramming factors (4F). However, while the best 4F srRNA efficiently generated iPSCs from young fibroblasts, it was inefficien...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531586/ https://www.ncbi.nlm.nih.gov/pubmed/28750082 http://dx.doi.org/10.1371/journal.pone.0182018 |