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Compensatory lung growth after bilobectomy in emphysematous rats

Lung volume reduction surgery (LVRS) is an option for emphysematous patients who are awaiting lung transplantation. LVRS reduces nonfunctional portions of lung tissues and favors the compensatory lung growth (CLG) of the remaining lobes. This phenomenon diminishes dyspnea and improves both the respi...

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Detalles Bibliográficos
Autores principales: Almeida, Francine Maria, Saraiva-Romanholo, Beatriz Mangueira, Vieira, Rodolfo Paula, Moriya, Henrique Takachi, Ligeiro-de-Oliveira, Ana Paula, Lopes, Fernanda DTQS, Castro-Faria-Neto, Hugo C., Mauad, Thais, Martins, Milton Arruda, Pazetti, Rogerio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531597/
https://www.ncbi.nlm.nih.gov/pubmed/28750097
http://dx.doi.org/10.1371/journal.pone.0181819
Descripción
Sumario:Lung volume reduction surgery (LVRS) is an option for emphysematous patients who are awaiting lung transplantation. LVRS reduces nonfunctional portions of lung tissues and favors the compensatory lung growth (CLG) of the remaining lobes. This phenomenon diminishes dyspnea and improves both the respiratory mechanics and quality of life for the patients. An animal model of elastase-induced pulmonary emphysema was used to investigate the structural and functional lung response after LVRS. Bilobectomy was performed six weeks after elastase instillation. Two weeks after bilobectomy, CLG effects were evaluated by lung mechanics and histomorphometric analysis. After bilobectomy, the emphysematous animals presented decreased mean linear intercepts, increased elastic fiber proportion, and increased alveolar surface density, total volumes of airspace, tissue and respiratory region and absolute surface area. We conclude that bilobectomy promoted CLG in emphysematous animals, resulting in alveolar architecture repair.