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Compensatory lung growth after bilobectomy in emphysematous rats
Lung volume reduction surgery (LVRS) is an option for emphysematous patients who are awaiting lung transplantation. LVRS reduces nonfunctional portions of lung tissues and favors the compensatory lung growth (CLG) of the remaining lobes. This phenomenon diminishes dyspnea and improves both the respi...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531597/ https://www.ncbi.nlm.nih.gov/pubmed/28750097 http://dx.doi.org/10.1371/journal.pone.0181819 |
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author | Almeida, Francine Maria Saraiva-Romanholo, Beatriz Mangueira Vieira, Rodolfo Paula Moriya, Henrique Takachi Ligeiro-de-Oliveira, Ana Paula Lopes, Fernanda DTQS Castro-Faria-Neto, Hugo C. Mauad, Thais Martins, Milton Arruda Pazetti, Rogerio |
author_facet | Almeida, Francine Maria Saraiva-Romanholo, Beatriz Mangueira Vieira, Rodolfo Paula Moriya, Henrique Takachi Ligeiro-de-Oliveira, Ana Paula Lopes, Fernanda DTQS Castro-Faria-Neto, Hugo C. Mauad, Thais Martins, Milton Arruda Pazetti, Rogerio |
author_sort | Almeida, Francine Maria |
collection | PubMed |
description | Lung volume reduction surgery (LVRS) is an option for emphysematous patients who are awaiting lung transplantation. LVRS reduces nonfunctional portions of lung tissues and favors the compensatory lung growth (CLG) of the remaining lobes. This phenomenon diminishes dyspnea and improves both the respiratory mechanics and quality of life for the patients. An animal model of elastase-induced pulmonary emphysema was used to investigate the structural and functional lung response after LVRS. Bilobectomy was performed six weeks after elastase instillation. Two weeks after bilobectomy, CLG effects were evaluated by lung mechanics and histomorphometric analysis. After bilobectomy, the emphysematous animals presented decreased mean linear intercepts, increased elastic fiber proportion, and increased alveolar surface density, total volumes of airspace, tissue and respiratory region and absolute surface area. We conclude that bilobectomy promoted CLG in emphysematous animals, resulting in alveolar architecture repair. |
format | Online Article Text |
id | pubmed-5531597 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-55315972017-08-07 Compensatory lung growth after bilobectomy in emphysematous rats Almeida, Francine Maria Saraiva-Romanholo, Beatriz Mangueira Vieira, Rodolfo Paula Moriya, Henrique Takachi Ligeiro-de-Oliveira, Ana Paula Lopes, Fernanda DTQS Castro-Faria-Neto, Hugo C. Mauad, Thais Martins, Milton Arruda Pazetti, Rogerio PLoS One Research Article Lung volume reduction surgery (LVRS) is an option for emphysematous patients who are awaiting lung transplantation. LVRS reduces nonfunctional portions of lung tissues and favors the compensatory lung growth (CLG) of the remaining lobes. This phenomenon diminishes dyspnea and improves both the respiratory mechanics and quality of life for the patients. An animal model of elastase-induced pulmonary emphysema was used to investigate the structural and functional lung response after LVRS. Bilobectomy was performed six weeks after elastase instillation. Two weeks after bilobectomy, CLG effects were evaluated by lung mechanics and histomorphometric analysis. After bilobectomy, the emphysematous animals presented decreased mean linear intercepts, increased elastic fiber proportion, and increased alveolar surface density, total volumes of airspace, tissue and respiratory region and absolute surface area. We conclude that bilobectomy promoted CLG in emphysematous animals, resulting in alveolar architecture repair. Public Library of Science 2017-07-27 /pmc/articles/PMC5531597/ /pubmed/28750097 http://dx.doi.org/10.1371/journal.pone.0181819 Text en © 2017 Almeida et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Almeida, Francine Maria Saraiva-Romanholo, Beatriz Mangueira Vieira, Rodolfo Paula Moriya, Henrique Takachi Ligeiro-de-Oliveira, Ana Paula Lopes, Fernanda DTQS Castro-Faria-Neto, Hugo C. Mauad, Thais Martins, Milton Arruda Pazetti, Rogerio Compensatory lung growth after bilobectomy in emphysematous rats |
title | Compensatory lung growth after bilobectomy in emphysematous rats |
title_full | Compensatory lung growth after bilobectomy in emphysematous rats |
title_fullStr | Compensatory lung growth after bilobectomy in emphysematous rats |
title_full_unstemmed | Compensatory lung growth after bilobectomy in emphysematous rats |
title_short | Compensatory lung growth after bilobectomy in emphysematous rats |
title_sort | compensatory lung growth after bilobectomy in emphysematous rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531597/ https://www.ncbi.nlm.nih.gov/pubmed/28750097 http://dx.doi.org/10.1371/journal.pone.0181819 |
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