Cargando…

Dissection of specific binding of HIV-1 Gag to the 'packaging signal' in viral RNA

Selective packaging of HIV-1 genomic RNA (gRNA) requires the presence of a cis-acting RNA element called the ‘packaging signal’ (Ψ). However, the mechanism by which Ψ promotes selective packaging of the gRNA is not well understood. We used fluorescence correlation spectroscopy and quenching data to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Comas-Garcia, Mauricio, Datta, Siddhartha AK, Baker, Laura, Varma, Rajat, Gudla, Prabhakar R, Rein, Alan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531834/ https://www.ncbi.nlm.nih.gov/pubmed/28726630 http://dx.doi.org/10.7554/eLife.27055

Ejemplares similares

Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies
por: Carlson, Lars-Anders, et al.
Publicado: (2016)

Binding mechanism of the matrix domain of HIV-1 gag on lipid membranes
por: Monje-Galvan, Viviana, et al.
Publicado: (2020)

Dissection of the interaction between the intrinsically disordered YAP protein and the transcription factor TEAD
por: Mesrouze, Yannick, et al.
Publicado: (2017)

Visualization and functional dissection of coaxial paired SpoIIIE channels across the sporulation septum
por: Shin, Jae Yen, et al.
Publicado: (2015)

Viral genome structures are optimal for capsid assembly
por: Perlmutter, Jason D, et al.
Publicado: (2013)

Complete dissection of transcription elongation reveals slow translocation of RNA polymerase II in a linear ratchet mechanism
por: Dangkulwanich, Manchuta, et al.
Publicado: (2013)

Efficient support of virus-like particle assembly by the HIV-1 packaging signal
por: Comas-Garcia, Mauricio, et al.
Publicado: (2018)

Side-binding proteins modulate actin filament dynamics
por: Crevenna, Alvaro H, et al.
Publicado: (2015)

Contacts-based prediction of binding affinity in protein–protein complexes
por: Vangone, Anna, et al.
Publicado: (2015)

The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat
por: Schulze-Gahmen, Ursula, et al.
Publicado: (2013)

Coupled ion binding and structural transitions along the transport cycle of glutamate transporters
por: Verdon, Grégory, et al.
Publicado: (2014)

Real-time observation of signal recognition particle binding to actively translating ribosomes
por: Noriega, Thomas R, et al.
Publicado: (2014)

Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta
por: Jiang, Lin, et al.
Publicado: (2013)

An internal thioester in a pathogen surface protein mediates covalent host binding
por: Walden, Miriam, et al.
Publicado: (2015)

Graphlet signature-based scoring method to estimate protein–ligand binding affinity
por: Singh, Omkar, et al.
Publicado: (2014)

STIL binding to Polo-box 3 of PLK4 regulates centriole duplication
por: Arquint, Christian, et al.
Publicado: (2015)

Guanylate binding proteins directly attack Toxoplasma gondii via supramolecular complexes
por: Kravets, Elisabeth, et al.
Publicado: (2016)

Structure and dynamics underlying elementary ligand binding events in human pacemaking channels
por: Goldschen-Ohm, Marcel P, et al.
Publicado: (2016)

Correction: Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta
por: Jiang, Lin, et al.
Publicado: (2013)

Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments
por: Tang, Shaogeng, et al.
Publicado: (2015)

Observation of long-range tertiary interactions during ligand binding by the TPP riboswitch aptamer
por: Duesterberg, Van K, et al.
Publicado: (2015)

An external sodium ion binding site controls allosteric gating in TRPV1 channels
por: Jara-Oseguera, Andres, et al.
Publicado: (2016)

The selectivity of the Na(+)/K(+)-pump is controlled by binding site protonation and self-correcting occlusion
por: Rui, Huan, et al.
Publicado: (2016)

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR
por: Erlendsson, Simon, et al.
Publicado: (2017)

Promiscuous binding by Hsp70 results in conformational heterogeneity and fuzzy chaperone-substrate ensembles
por: Rosenzweig, Rina, et al.
Publicado: (2017)

Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection
por: Derebe, Mehabaw G, et al.
Publicado: (2014)

Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
por: Atherton, Joseph, et al.
Publicado: (2014)

Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio
por: Weidmann, Chase A, et al.
Publicado: (2016)

Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones
por: Wilkinson, Martin, et al.
Publicado: (2016)

Structural dynamics of E. coli single-stranded DNA binding protein reveal DNA wrapping and unwrapping pathways
por: Suksombat, Sukrit, et al.
Publicado: (2015)

Folding behavior of a T-shaped, ribosome-binding translation enhancer implicated in a wide-spread conformational switch
por: Le, My-Tra, et al.
Publicado: (2017)

AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter
por: Schulze-Gahmen, Ursula, et al.
Publicado: (2014)

The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix
por: Barneda, David, et al.
Publicado: (2015)

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2
por: Diao, Jiajie, et al.
Publicado: (2013)

Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion
por: Sitarska, Ewa, et al.
Publicado: (2017)

Robust and accurate prediction of residue–residue interactions across protein interfaces using evolutionary information
por: Ovchinnikov, Sergey, et al.
Publicado: (2014)

Convergent weaponry in a biological arms race
por: Baker, Edward N, et al.
Publicado: (2015)

NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors
por: Wu, Dalei, et al.
Publicado: (2016)

Changes in the free-energy landscape of p38α MAP kinase through its canonical activation and binding events as studied by enhanced molecular dynamics simulations
por: Kuzmanic, Antonija, et al.
Publicado: (2017)

Problems on the back of an envelope
por: Anikeeva, Polina, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_mftf9tped5aia93beu986pio90