CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer

Genes whose function is selectively essential in the presence of cancer-associated genetic aberrations represent promising targets for the development of precision therapeutics. Here, we present CancerGD, a resource that integrates genotypic profiling with large-scale loss-of-function genetic screen...

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Detalles Bibliográficos
Autores principales: Bridgett, Stephen, Campbell, James, Lord, Christopher J., Ryan, Colm J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Tool
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531859/
https://www.ncbi.nlm.nih.gov/pubmed/28711281
http://dx.doi.org/10.1016/j.cels.2017.06.002
Descripción
Sumario:Genes whose function is selectively essential in the presence of cancer-associated genetic aberrations represent promising targets for the development of precision therapeutics. Here, we present CancerGD, a resource that integrates genotypic profiling with large-scale loss-of-function genetic screens in tumor cell lines to identify such genetic dependencies. CancerGD provides tools for searching, visualizing, and interpreting these genetic dependencies through the integration of functional interaction networks. CancerGD includes different screen types (siRNA, shRNA, CRISPR), and we describe a simple format for submitting new datasets.

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