CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer

Genes whose function is selectively essential in the presence of cancer-associated genetic aberrations represent promising targets for the development of precision therapeutics. Here, we present CancerGD, a resource that integrates genotypic profiling with large-scale loss-of-function genetic screen...

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Detalles Bibliográficos
Autores principales: Bridgett, Stephen, Campbell, James, Lord, Christopher J., Ryan, Colm J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Tool
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531859/
https://www.ncbi.nlm.nih.gov/pubmed/28711281
http://dx.doi.org/10.1016/j.cels.2017.06.002
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author Bridgett, Stephen
Campbell, James
Lord, Christopher J.
Ryan, Colm J.
author_facet Bridgett, Stephen
Campbell, James
Lord, Christopher J.
Ryan, Colm J.
author_sort Bridgett, Stephen
collection PubMed
description Genes whose function is selectively essential in the presence of cancer-associated genetic aberrations represent promising targets for the development of precision therapeutics. Here, we present CancerGD, a resource that integrates genotypic profiling with large-scale loss-of-function genetic screens in tumor cell lines to identify such genetic dependencies. CancerGD provides tools for searching, visualizing, and interpreting these genetic dependencies through the integration of functional interaction networks. CancerGD includes different screen types (siRNA, shRNA, CRISPR), and we describe a simple format for submitting new datasets.
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spelling pubmed-55318592017-08-08 CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer Bridgett, Stephen Campbell, James Lord, Christopher J. Ryan, Colm J. Cell Syst Tool Genes whose function is selectively essential in the presence of cancer-associated genetic aberrations represent promising targets for the development of precision therapeutics. Here, we present CancerGD, a resource that integrates genotypic profiling with large-scale loss-of-function genetic screens in tumor cell lines to identify such genetic dependencies. CancerGD provides tools for searching, visualizing, and interpreting these genetic dependencies through the integration of functional interaction networks. CancerGD includes different screen types (siRNA, shRNA, CRISPR), and we describe a simple format for submitting new datasets. Cell Press 2017-07-26 /pmc/articles/PMC5531859/ /pubmed/28711281 http://dx.doi.org/10.1016/j.cels.2017.06.002 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Tool
Bridgett, Stephen
Campbell, James
Lord, Christopher J.
Ryan, Colm J.
CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer
title CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer
title_full CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer
title_fullStr CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer
title_full_unstemmed CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer
title_short CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer
title_sort cancergd: a resource for identifying and interpreting genetic dependencies in cancer
topic Tool
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531859/
https://www.ncbi.nlm.nih.gov/pubmed/28711281
http://dx.doi.org/10.1016/j.cels.2017.06.002
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