CALHM1-Mediated ATP Release and Ciliary Beat Frequency Modulation in Nasal Epithelial Cells

Mechanical stimulation of airway epithelial cells causes apical release of ATP, which increases ciliary beat frequency (CBF) and speeds up mucociliary clearance. The mechanisms responsible for this ATP release are poorly understood. CALHM1, a transmembrane protein with shared structural features to...

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Detalles Bibliográficos
Autores principales: Workman, Alan D., Carey, Ryan M., Chen, Bei, Saunders, Cecil J., Marambaud, Philippe, Mitchell, Claire H., Tordoff, Michael G., Lee, Robert J., Cohen, Noam A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532211/
https://www.ncbi.nlm.nih.gov/pubmed/28751666
http://dx.doi.org/10.1038/s41598-017-07221-9

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