Cell-cycle arrest in mature adipocytes impairs BAT development but not WAT browning, and reduces adaptive thermogenesis in mice

We previously reported brown adipocytes can proliferate even after differentiation. To test the involvement of mature adipocyte proliferation in cell number control in fat tissue, we generated transgenic (Tg) mice over-expressing cell-cycle inhibitory protein p27 specifically in adipocytes, using th...

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Detalles Bibliográficos
Autores principales: Okamatsu-Ogura, Yuko, Fukano, Keigo, Tsubota, Ayumi, Nio-Kobayashi, Junko, Nakamura, Kyoko, Morimatsu, Masami, Sakaue, Hiroshi, Saito, Masayuki, Kimura, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532220/
https://www.ncbi.nlm.nih.gov/pubmed/28751675
http://dx.doi.org/10.1038/s41598-017-07206-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532220/
https://www.ncbi.nlm.nih.gov/pubmed/28751675
http://dx.doi.org/10.1038/s41598-017-07206-8

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