Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia

In preeclampsia, the serum levels of transthyretin, a carrier protein for thyroxine, are elevated. Transthyretin isolated from preeclamptic serum is also aggregated and can induce preeclampsia-like symptoms in pregnant IL10(−/−) mice. Using western blotting, immunofluorescence, ELISA and qRT-PCR, we...

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Detalles Bibliográficos
Autores principales: Tong, Mancy, Cheng, Shi-bin, Chen, Qi, DeSousa, Joana, Stone, Peter R., James, Joanna L., Chamley, Lawrence W., Sharma, Surendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532246/
https://www.ncbi.nlm.nih.gov/pubmed/28751735
http://dx.doi.org/10.1038/s41598-017-07017-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532246/
https://www.ncbi.nlm.nih.gov/pubmed/28751735
http://dx.doi.org/10.1038/s41598-017-07017-x

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