Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy

Human corneal endothelial cells (HCEnCs) are terminally differentiated cells that have limited regenerative potential. The large numbers of mitochondria in HCEnCs are critical for pump and barrier function required for corneal hydration and transparency. Fuchs Endothelial Corneal Dystrophy (FECD) is...

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Detalles Bibliográficos
Autores principales: Benischke, Anne-Sophie, Vasanth, Shivakumar, Miyai, Takashi, Katikireddy, Kishore Reddy, White, Tomas, Chen, Yuming, Halilovic, Adna, Price, Marianne, Price, Francis, Liton, Paloma B., Jurkunas, Ula V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532298/
https://www.ncbi.nlm.nih.gov/pubmed/28751712
http://dx.doi.org/10.1038/s41598-017-06523-2

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