Targeted DNA methylation in human cells using engineered dCas9-methyltransferases

Mammalian genomes exhibit complex patterns of gene expression regulated, in part, by DNA methylation. The advent of engineered DNA methyltransferases (MTases) to target DNA methylation to specific sites in the genome will accelerate many areas of biological research. However, targeted MTases require...

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Detalles Bibliográficos
Autores principales: Xiong, Tina, Meister, Glenna E., Workman, Rachael E., Kato, Nathaniel C., Spellberg, Michael J., Turker, Fulya, Timp, Winston, Ostermeier, Marc, Novina, Carl D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532369/
https://www.ncbi.nlm.nih.gov/pubmed/28751638
http://dx.doi.org/10.1038/s41598-017-06757-0

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