Normalized Synergy Predicts That CD8 Co-Receptor Contribution to T Cell Receptor (TCR) and pMHC Binding Decreases As TCR Affinity Increases in Human Viral-Specific T Cells

The discovery of naturally occurring T cell receptors (TCRs) that confer specific, high-affinity recognition of pathogen and cancer-associated antigens remains a major goal in cellular immunotherapies. The contribution of the CD8 co-receptor to the interaction between the TCR and peptide-bound major...

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Detalles Bibliográficos
Autores principales: Williams, Chad M., Schonnesen, Alexandra A., Zhang, Shu-Qi, Ma, Ke-Yue, He, Chenfeng, Yamamoto, Tori, Eckhardt, S. Gail, Klebanoff, Christopher A., Jiang, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532383/
https://www.ncbi.nlm.nih.gov/pubmed/28804489
http://dx.doi.org/10.3389/fimmu.2017.00894

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