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Eribulin shows high concentration and long retention in xenograft tumor tissues

PURPOSE: Eribulin, a synthetic analog of the natural product halichondrin B, is a microtubule dynamics inhibitor. In this study, we report the pharmacokinetic profiles of eribulin in mice, rats, and dogs following intravenous administrations with optimized and validated bio-analytical methods. METHO...

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Detalles Bibliográficos
Autores principales:	Sugawara, Michiko, Condon, Krista, Liang, Earvin, DesJardins, Christopher, Schuck, Edgar, Kusano, Kazutomi, Lai, W. George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532402/ https://www.ncbi.nlm.nih.gov/pubmed/28664226 http://dx.doi.org/10.1007/s00280-017-3369-7

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