Cargando…

RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis

OBJECTIVE: The gross majority of colorectal cancer cases results from aberrant Wnt/β-catenin signalling through adenomatous polyposis coli (APC) or CTNNB1 mutations. However, a subset of human colon tumours harbour, mutually exclusive with APC and CTNNB1 mutations, gene fusions in RSPO2 or RSPO3, le...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hilkens, John, Timmer, Nikki C, Boer, Mandy, Ikink, Gerjon J, Schewe, Matthias, Sacchetti, Andrea, Koppens, Martijn A J, Song, Ji-Ying, Bakker, Elvira R M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2017
Materias:	GI cancer
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532462/ https://www.ncbi.nlm.nih.gov/pubmed/27511199 http://dx.doi.org/10.1136/gutjnl-2016-311606

Ejemplares similares

IRS4 induces mammary tumorigenesis and confers resistance to HER2-targeted therapy through constitutive PI3K/AKT-pathway hyperactivation
por: Ikink, Gerjon J., et al.
Publicado: (2016)

Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis
por: Peignon, Grégory, et al.
Publicado: (2011)

β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis
por: van Veelen, Wendy, et al.
Publicado: (2011)

Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2(loxP/loxP) Villin-Cre mice
por: Kortüm, Benedikt, et al.
Publicado: (2015)

Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy
por: Zhao, Yue, et al.
Publicado: (2018)

Subclonal diversity arises early even in small colorectal tumours and contributes to differential growth fates
por: Sievers, Chelsie K, et al.
Publicado: (2017)

Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers
por: Carotenuto, Pietro, et al.
Publicado: (2017)

Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture
por: Grillet, Fanny, et al.
Publicado: (2017)

Targeting cancer-associated fibroblast-secreted WNT2 restores dendritic cell-mediated antitumour immunity
por: Huang, Tu-Xiong, et al.
Publicado: (2022)

Activation of the GPR35 pathway drives angiogenesis in the tumour microenvironment
por: Pagano, Ester, et al.
Publicado: (2022)

Next-generation sequencing of bile cell-free DNA for the early detection of patients with malignant biliary strictures
por: Arechederra, Maria, et al.
Publicado: (2022)

Phase II trial of weekly erlotinib dosing to reduce duodenal polyp burden associated with familial adenomatous polyposis
por: Samadder, N Jewel, et al.
Publicado: (2023)

Methionine deficiency facilitates antitumour immunity by altering m(6)A methylation of immune checkpoint transcripts
por: Li, Ting, et al.
Publicado: (2023)

Insulin receptor substrate 4 (IRS4) is a constitutive active oncogenic driver collaborating with HER2 and causing therapeutic resistance
por: Ikink, Gerjon J., et al.
Publicado: (2017)

Insertional mutagenesis in a HER2-positive breast cancer model reveals ERAS as a driver of cancer and therapy resistance
por: Ikink, Gerjon J., et al.
Publicado: (2018)

EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers
por: Smyth, Elizabeth C, et al.
Publicado: (2021)

R‐spondin‐3 is an oncogenic driver of poorly differentiated invasive breast cancer
por: ter Steege, Eline J, et al.
Publicado: (2022)

Recent advances in intestinal imaging
por: Sinha, Rakesh
Publicado: (2011)

CT features, mimics and atypical presentations of gastrointestinal stromal tumor (GIST)
por: Sripathi, Smiti, et al.
Publicado: (2011)

Gastrointestinal Image: A True Giant Transverse Colon Diverticulum
por: Olakowski, Marek, et al.
Publicado: (2011)

Inverted Meckel’s Diverticulum with Ectopic Pancreatic Tissue as a Source of Severe Gastrointestinal Bleeding
por: Kopáčová, Marcela, et al.
Publicado: (2009)

Primary Hepatic Osteosarcoma
por: Nawabi, Atta, et al.
Publicado: (2009)

Torsion of the Gallbladder
por: Boonstra, Elizabeth A., et al.
Publicado: (2011)

In the workup of patients with obscure gastrointestinal bleed, does 64-slice MDCT have a role?
por: Kulkarni, Chinmay, et al.
Publicado: (2012)

CT scan diagnosis of hepatic adenoma in a case of von Gierke disease
por: Daga, Bipin Valchandji, et al.
Publicado: (2012)

Upper gastrointestinal haemorrhage and deprivation: a nationwide cohort study of health inequality in hospital admissions
por: Crooks, Colin J, et al.
Publicado: (2011)

A Focal Mass-Forming Autoimmune Pancreatitis Mimicking Pancreatic Cancer with Obstruction of the Main Pancreatic Duct
por: Matsumoto, Ippei, et al.
Publicado: (2011)

Minimally invasive single-site surgery for the digestive system: A technological review
por: Dhumane, Parag W, et al.
Publicado: (2011)

Minimal invasive single-site surgery in colorectal procedures: Current state of the art
por: Diana, Michele, et al.
Publicado: (2011)

Pictorial essay: CT scan of appendicitis and its mimics causing right lower quadrant pain
por: Sharma, Monika, et al.
Publicado: (2008)

Emergency Repair of Giant Inguinoscrotal Hernia in a Septic Patient
por: Gaedcke, J., et al.
Publicado: (2013)

Endoscopic stent insertion for anastomotic leakage following oesophagectomy
por: Schweigert, M, et al.
Publicado: (2013)

Cardiopulmonary exercise testing as a predictor of complications in oesophagogastric cancer surgery
por: Moyes, LH, et al.
Publicado: (2013)

Single incision laparoscopic adjustable gastric band: technique, feasibility, safety and learning curve
por: Osborne, AJ, et al.
Publicado: (2013)

Abdominopelvic Splenosis—An Unusual Cause of Tenesmus
por: Cheung, King Kenneth, et al.
Publicado: (2014)

MRI enterography with divided dose oral preparation: Effect on bowel distension and diagnostic quality
por: Sinha, Rakesh, et al.
Publicado: (2013)

Does conventional defecography has a role to play in evaluation of evacuatory disorders in Indian population?
por: Kumar, Sheo, et al.
Publicado: (2013)

Understanding the natural history of focal nodular hyperplasia in the liver with MRI
por: Halankar, Jaydeep A, et al.
Publicado: (2012)

Endoscopic retrograde cholangiopancreatography in the treatment of intraoperatively demonstrated choledocholithiasis
por: Lynn, AP, et al.
Publicado: (2014)

Hepatosteatosis from Lysosomal Acid Lipase Deficiency
por: Zandanell, Stephan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_al86n2uftbi2da56aeb5oi4tsf