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Sino-Nasal 5 Questionnaire is Associated with Poor Asthma Control in Children with Asthma

Up to 80% of asthmatic children may experience upper airway symptoms which are often perceived as coming from the lower airways. Currently, there are no validated questionnaires to assess upper airway contribution to pediatric asthma symptoms. The Sino-Nasal 5 (SN-5) questionnaire was previously val...

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Autores principales: Kilaikode, Sasikumar, Shukla, Prateek J., Phull, Gurpreet, Jackson, James H., Prue, Dominique C., Martinez, Claudia, Scheffey, Krista, Pillai, Dinesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532546/
https://www.ncbi.nlm.nih.gov/pubmed/28657592
http://dx.doi.org/10.3390/children4070054
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author Kilaikode, Sasikumar
Shukla, Prateek J.
Phull, Gurpreet
Jackson, James H.
Prue, Dominique C.
Martinez, Claudia
Scheffey, Krista
Pillai, Dinesh K.
author_facet Kilaikode, Sasikumar
Shukla, Prateek J.
Phull, Gurpreet
Jackson, James H.
Prue, Dominique C.
Martinez, Claudia
Scheffey, Krista
Pillai, Dinesh K.
author_sort Kilaikode, Sasikumar
collection PubMed
description Up to 80% of asthmatic children may experience upper airway symptoms which are often perceived as coming from the lower airways. Currently, there are no validated questionnaires to assess upper airway contribution to pediatric asthma symptoms. The Sino-Nasal 5 (SN-5) questionnaire was previously validated for identifying radiographic confirmed sinus disease in children. In this study, we hypothesize that significant SN-5 scores (≥3.5) are associated with abnormal National Asthma Education and Prevention Program (NAEPP) based asthma impairment and control in asthmatic children. Retrospective data collected on children with asthma referred for pulmonary evaluation included age, gender, ethnicity, NAEPP asthma severity, asthma control (Test for Respiratory and Asthma Control in Kids (TRACK) < 5 years, Asthma Control Test (ACT) 5 years) and pulmonary function testing. Associations between SN-5 scores and asthma impairment and control were identified. Seventy-six children were evaluated; 38% were female with a mean age of 6.9 years. Significant SN-5 scores were associated with decreased control of daytime symptoms (odds ratio (OR): 0.16 (95% confidence interval (CI): 0.06–0.44)), night time awakenings (0.09 (0.03–0.29)), activity interference (0.2 (0.06–0.68)), NAEPP defined asthma control (0.32 (0.12–0.85)) and poor asthma control based on TRACK (p < 0.001) and ACT (p < 0.001). This suggests upper airways may play a larger role in perceived lower airway symptoms, and SN-5 may be beneficial in assessing the contribution of upper airway conditions on asthma control.
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spelling pubmed-55325462017-08-07 Sino-Nasal 5 Questionnaire is Associated with Poor Asthma Control in Children with Asthma Kilaikode, Sasikumar Shukla, Prateek J. Phull, Gurpreet Jackson, James H. Prue, Dominique C. Martinez, Claudia Scheffey, Krista Pillai, Dinesh K. Children (Basel) Article Up to 80% of asthmatic children may experience upper airway symptoms which are often perceived as coming from the lower airways. Currently, there are no validated questionnaires to assess upper airway contribution to pediatric asthma symptoms. The Sino-Nasal 5 (SN-5) questionnaire was previously validated for identifying radiographic confirmed sinus disease in children. In this study, we hypothesize that significant SN-5 scores (≥3.5) are associated with abnormal National Asthma Education and Prevention Program (NAEPP) based asthma impairment and control in asthmatic children. Retrospective data collected on children with asthma referred for pulmonary evaluation included age, gender, ethnicity, NAEPP asthma severity, asthma control (Test for Respiratory and Asthma Control in Kids (TRACK) < 5 years, Asthma Control Test (ACT) 5 years) and pulmonary function testing. Associations between SN-5 scores and asthma impairment and control were identified. Seventy-six children were evaluated; 38% were female with a mean age of 6.9 years. Significant SN-5 scores were associated with decreased control of daytime symptoms (odds ratio (OR): 0.16 (95% confidence interval (CI): 0.06–0.44)), night time awakenings (0.09 (0.03–0.29)), activity interference (0.2 (0.06–0.68)), NAEPP defined asthma control (0.32 (0.12–0.85)) and poor asthma control based on TRACK (p < 0.001) and ACT (p < 0.001). This suggests upper airways may play a larger role in perceived lower airway symptoms, and SN-5 may be beneficial in assessing the contribution of upper airway conditions on asthma control. MDPI 2017-06-28 /pmc/articles/PMC5532546/ /pubmed/28657592 http://dx.doi.org/10.3390/children4070054 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kilaikode, Sasikumar
Shukla, Prateek J.
Phull, Gurpreet
Jackson, James H.
Prue, Dominique C.
Martinez, Claudia
Scheffey, Krista
Pillai, Dinesh K.
Sino-Nasal 5 Questionnaire is Associated with Poor Asthma Control in Children with Asthma
title Sino-Nasal 5 Questionnaire is Associated with Poor Asthma Control in Children with Asthma
title_full Sino-Nasal 5 Questionnaire is Associated with Poor Asthma Control in Children with Asthma
title_fullStr Sino-Nasal 5 Questionnaire is Associated with Poor Asthma Control in Children with Asthma
title_full_unstemmed Sino-Nasal 5 Questionnaire is Associated with Poor Asthma Control in Children with Asthma
title_short Sino-Nasal 5 Questionnaire is Associated with Poor Asthma Control in Children with Asthma
title_sort sino-nasal 5 questionnaire is associated with poor asthma control in children with asthma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532546/
https://www.ncbi.nlm.nih.gov/pubmed/28657592
http://dx.doi.org/10.3390/children4070054
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