Sterols from the Octocoral Nephthea columnaris

Two new sterols, columnaristerols B (1) and C (2), along with two known analogues, 5,6-epoxylitosterol (3) and litosterol (4), were obtained from the octocoral Nephthea columnaris. The structures of new sterols 1 and 2 were elucidated by using spectroscopic methods and comparing the spectroscopic da...

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Autores principales: Whuang, Ta-Yuan, Tsai, Hong-Chieh, Su, Yin-Di, Hwang, Tsong-Long, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532654/
https://www.ncbi.nlm.nih.gov/pubmed/28677628
http://dx.doi.org/10.3390/md15070212
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author Whuang, Ta-Yuan
Tsai, Hong-Chieh
Su, Yin-Di
Hwang, Tsong-Long
Sung, Ping-Jyun
author_facet Whuang, Ta-Yuan
Tsai, Hong-Chieh
Su, Yin-Di
Hwang, Tsong-Long
Sung, Ping-Jyun
author_sort Whuang, Ta-Yuan
collection PubMed
description Two new sterols, columnaristerols B (1) and C (2), along with two known analogues, 5,6-epoxylitosterol (3) and litosterol (4), were obtained from the octocoral Nephthea columnaris. The structures of new sterols 1 and 2 were elucidated by using spectroscopic methods and comparing the spectroscopic data with those of known related metabolites. Sterol 3 was found to suppress superoxide anion production and elastase secretion by human neutrophils.
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spelling pubmed-55326542017-08-09 Sterols from the Octocoral Nephthea columnaris Whuang, Ta-Yuan Tsai, Hong-Chieh Su, Yin-Di Hwang, Tsong-Long Sung, Ping-Jyun Mar Drugs Article Two new sterols, columnaristerols B (1) and C (2), along with two known analogues, 5,6-epoxylitosterol (3) and litosterol (4), were obtained from the octocoral Nephthea columnaris. The structures of new sterols 1 and 2 were elucidated by using spectroscopic methods and comparing the spectroscopic data with those of known related metabolites. Sterol 3 was found to suppress superoxide anion production and elastase secretion by human neutrophils. MDPI 2017-07-04 /pmc/articles/PMC5532654/ /pubmed/28677628 http://dx.doi.org/10.3390/md15070212 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Whuang, Ta-Yuan
Tsai, Hong-Chieh
Su, Yin-Di
Hwang, Tsong-Long
Sung, Ping-Jyun
Sterols from the Octocoral Nephthea columnaris
title Sterols from the Octocoral Nephthea columnaris
title_full Sterols from the Octocoral Nephthea columnaris
title_fullStr Sterols from the Octocoral Nephthea columnaris
title_full_unstemmed Sterols from the Octocoral Nephthea columnaris
title_short Sterols from the Octocoral Nephthea columnaris
title_sort sterols from the octocoral nephthea columnaris
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532654/
https://www.ncbi.nlm.nih.gov/pubmed/28677628
http://dx.doi.org/10.3390/md15070212
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