Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207

A novel indole, microindolinone A (1), was isolated from a deep-sea-derived actinomycete Microbacterium sp. MCCC 1A11207, together with 18 known compounds (2–19). By detailed analysis of the (1)H, (13)C, HSQC, COSY, HMBC, high resolution electron spray ionization mass spectrum (HRESIMS), and circula...

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Detalles Bibliográficos
Autores principales: Niu, Siwen, Zhou, Ting-Ting, Xie, Chun-Lan, Zhang, Gai-Yun, Yang, Xian-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532672/
https://www.ncbi.nlm.nih.gov/pubmed/28753937
http://dx.doi.org/10.3390/md15070230
Descripción
Sumario:A novel indole, microindolinone A (1), was isolated from a deep-sea-derived actinomycete Microbacterium sp. MCCC 1A11207, together with 18 known compounds (2–19). By detailed analysis of the (1)H, (13)C, HSQC, COSY, HMBC, high resolution electron spray ionization mass spectrum (HRESIMS), and circular dichroism (CD) data, the absolute configuration of 1 was elucidated as 5R-hydroxy-4,5,6,7-tetrahydroindole-4-one. It is noteworthy that 1 is the second example of a saturated indole isolated from nature.

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