Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207

A novel indole, microindolinone A (1), was isolated from a deep-sea-derived actinomycete Microbacterium sp. MCCC 1A11207, together with 18 known compounds (2–19). By detailed analysis of the (1)H, (13)C, HSQC, COSY, HMBC, high resolution electron spray ionization mass spectrum (HRESIMS), and circula...

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Autores principales: Niu, Siwen, Zhou, Ting-Ting, Xie, Chun-Lan, Zhang, Gai-Yun, Yang, Xian-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532672/
https://www.ncbi.nlm.nih.gov/pubmed/28753937
http://dx.doi.org/10.3390/md15070230
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author Niu, Siwen
Zhou, Ting-Ting
Xie, Chun-Lan
Zhang, Gai-Yun
Yang, Xian-Wen
author_facet Niu, Siwen
Zhou, Ting-Ting
Xie, Chun-Lan
Zhang, Gai-Yun
Yang, Xian-Wen
author_sort Niu, Siwen
collection PubMed
description A novel indole, microindolinone A (1), was isolated from a deep-sea-derived actinomycete Microbacterium sp. MCCC 1A11207, together with 18 known compounds (2–19). By detailed analysis of the (1)H, (13)C, HSQC, COSY, HMBC, high resolution electron spray ionization mass spectrum (HRESIMS), and circular dichroism (CD) data, the absolute configuration of 1 was elucidated as 5R-hydroxy-4,5,6,7-tetrahydroindole-4-one. It is noteworthy that 1 is the second example of a saturated indole isolated from nature.
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spelling pubmed-55326722017-08-09 Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207 Niu, Siwen Zhou, Ting-Ting Xie, Chun-Lan Zhang, Gai-Yun Yang, Xian-Wen Mar Drugs Communication A novel indole, microindolinone A (1), was isolated from a deep-sea-derived actinomycete Microbacterium sp. MCCC 1A11207, together with 18 known compounds (2–19). By detailed analysis of the (1)H, (13)C, HSQC, COSY, HMBC, high resolution electron spray ionization mass spectrum (HRESIMS), and circular dichroism (CD) data, the absolute configuration of 1 was elucidated as 5R-hydroxy-4,5,6,7-tetrahydroindole-4-one. It is noteworthy that 1 is the second example of a saturated indole isolated from nature. MDPI 2017-07-19 /pmc/articles/PMC5532672/ /pubmed/28753937 http://dx.doi.org/10.3390/md15070230 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Niu, Siwen
Zhou, Ting-Ting
Xie, Chun-Lan
Zhang, Gai-Yun
Yang, Xian-Wen
Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207
title Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207
title_full Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207
title_fullStr Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207
title_full_unstemmed Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207
title_short Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207
title_sort microindolinone a, a novel 4,5,6,7-tetrahydroindole, from the deep-sea-derived actinomycete microbacterium sp. mccc 1a11207
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532672/
https://www.ncbi.nlm.nih.gov/pubmed/28753937
http://dx.doi.org/10.3390/md15070230
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