Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle

Serious disease outbreaks in cattle caused by Theileria orientalis have emerged in the Asia–Pacific region. Genetic variables of the major piroplasm surface protein (MPSP) expressed on the surface of the piroplasm inside T. orientalis-infected erythrocytes are considered to be associated with variat...

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Autores principales: Kim, Suhee, Yu, Do-Hyeon, Chae, Jeong-Byoung, Choi, Kyoung-Seong, Kim, Hyeon-Cheol, Park, Bae-Keun, Chae, Joon-Seok, Park, Jinho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532781/
https://www.ncbi.nlm.nih.gov/pubmed/28750636
http://dx.doi.org/10.1186/s13028-017-0318-8
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author Kim, Suhee
Yu, Do-Hyeon
Chae, Jeong-Byoung
Choi, Kyoung-Seong
Kim, Hyeon-Cheol
Park, Bae-Keun
Chae, Joon-Seok
Park, Jinho
author_facet Kim, Suhee
Yu, Do-Hyeon
Chae, Jeong-Byoung
Choi, Kyoung-Seong
Kim, Hyeon-Cheol
Park, Bae-Keun
Chae, Joon-Seok
Park, Jinho
author_sort Kim, Suhee
collection PubMed
description Serious disease outbreaks in cattle caused by Theileria orientalis have emerged in the Asia–Pacific region. Genetic variables of the major piroplasm surface protein (MPSP) expressed on the surface of the piroplasm inside T. orientalis-infected erythrocytes are considered to be associated with variation in the pathogenicity of T. orientalis. Our study describes the clinically relevant MPSP types associated with anemia in Theileria-infected cattle. These results revealed that MPSP expression plays an important role in hematological alterations in Theileria-infected cattle, and that MPSP type 1 is strongly associated with bovine anemia, which can be a potential target for the prevention of bovine theileriosis.
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spelling pubmed-55327812017-08-02 Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle Kim, Suhee Yu, Do-Hyeon Chae, Jeong-Byoung Choi, Kyoung-Seong Kim, Hyeon-Cheol Park, Bae-Keun Chae, Joon-Seok Park, Jinho Acta Vet Scand Brief Communication Serious disease outbreaks in cattle caused by Theileria orientalis have emerged in the Asia–Pacific region. Genetic variables of the major piroplasm surface protein (MPSP) expressed on the surface of the piroplasm inside T. orientalis-infected erythrocytes are considered to be associated with variation in the pathogenicity of T. orientalis. Our study describes the clinically relevant MPSP types associated with anemia in Theileria-infected cattle. These results revealed that MPSP expression plays an important role in hematological alterations in Theileria-infected cattle, and that MPSP type 1 is strongly associated with bovine anemia, which can be a potential target for the prevention of bovine theileriosis. BioMed Central 2017-07-27 /pmc/articles/PMC5532781/ /pubmed/28750636 http://dx.doi.org/10.1186/s13028-017-0318-8 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Brief Communication
Kim, Suhee
Yu, Do-Hyeon
Chae, Jeong-Byoung
Choi, Kyoung-Seong
Kim, Hyeon-Cheol
Park, Bae-Keun
Chae, Joon-Seok
Park, Jinho
Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle
title Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle
title_full Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle
title_fullStr Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle
title_full_unstemmed Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle
title_short Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle
title_sort pathogenic genotype of major piroplasm surface protein associated with anemia in theileria orientalis infection in cattle
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532781/
https://www.ncbi.nlm.nih.gov/pubmed/28750636
http://dx.doi.org/10.1186/s13028-017-0318-8
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