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Disintegration Test of Health Food Products Containing Ginkgo Biloba L. or Vitex Agnus-Castus L. in the Japanese Market

For many years now, a number of Western herbs have been widely used in health food products in Japan and as pharmaceuticals in Europe. There are few or no mandated criteria concerning the quality of these herbal health food products, thus clarification is warranted. Here, we performed disintegration...

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Autores principales: Sato-Masumoto, Naoko, Masada, Sayaka, Takahashi, Satoshi, Terasaki, Sachiko, Yokota, Yoichi, Hakamatsuka, Takashi, Goda, Yukihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533160/
https://www.ncbi.nlm.nih.gov/pubmed/28930200
http://dx.doi.org/10.3390/medicines2020047
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author Sato-Masumoto, Naoko
Masada, Sayaka
Takahashi, Satoshi
Terasaki, Sachiko
Yokota, Yoichi
Hakamatsuka, Takashi
Goda, Yukihiro
author_facet Sato-Masumoto, Naoko
Masada, Sayaka
Takahashi, Satoshi
Terasaki, Sachiko
Yokota, Yoichi
Hakamatsuka, Takashi
Goda, Yukihiro
author_sort Sato-Masumoto, Naoko
collection PubMed
description For many years now, a number of Western herbs have been widely used in health food products in Japan and as pharmaceuticals in Europe. There are few or no mandated criteria concerning the quality of these herbal health food products, thus clarification is warranted. Here, we performed disintegration tests of 26 pharmaceutical and health food products containing the Western herbs ginkgo leaf and chaste tree fruit, in accord with the Japanese Pharmacopoeia. All eight pharmaceutical herbal products found in the European market completely disintegrated within the defined test time, and 11 of the 18 tested herbal products distributed as health foods in Japan disintegrated. Among the incompatible products identified in the Pharmacopoeia test, some products remained intact after incubation in water for 60 min. To ensure the efficacy of Western herbal products sold as health food in Japan, quality control, including disintegration, is therefore recommended, even though these products are not regulated under the Pharmaceutical Affairs Law.
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spelling pubmed-55331602017-09-14 Disintegration Test of Health Food Products Containing Ginkgo Biloba L. or Vitex Agnus-Castus L. in the Japanese Market Sato-Masumoto, Naoko Masada, Sayaka Takahashi, Satoshi Terasaki, Sachiko Yokota, Yoichi Hakamatsuka, Takashi Goda, Yukihiro Medicines (Basel) Article For many years now, a number of Western herbs have been widely used in health food products in Japan and as pharmaceuticals in Europe. There are few or no mandated criteria concerning the quality of these herbal health food products, thus clarification is warranted. Here, we performed disintegration tests of 26 pharmaceutical and health food products containing the Western herbs ginkgo leaf and chaste tree fruit, in accord with the Japanese Pharmacopoeia. All eight pharmaceutical herbal products found in the European market completely disintegrated within the defined test time, and 11 of the 18 tested herbal products distributed as health foods in Japan disintegrated. Among the incompatible products identified in the Pharmacopoeia test, some products remained intact after incubation in water for 60 min. To ensure the efficacy of Western herbal products sold as health food in Japan, quality control, including disintegration, is therefore recommended, even though these products are not regulated under the Pharmaceutical Affairs Law. MDPI 2015-04-23 /pmc/articles/PMC5533160/ /pubmed/28930200 http://dx.doi.org/10.3390/medicines2020047 Text en © 2015 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sato-Masumoto, Naoko
Masada, Sayaka
Takahashi, Satoshi
Terasaki, Sachiko
Yokota, Yoichi
Hakamatsuka, Takashi
Goda, Yukihiro
Disintegration Test of Health Food Products Containing Ginkgo Biloba L. or Vitex Agnus-Castus L. in the Japanese Market
title Disintegration Test of Health Food Products Containing Ginkgo Biloba L. or Vitex Agnus-Castus L. in the Japanese Market
title_full Disintegration Test of Health Food Products Containing Ginkgo Biloba L. or Vitex Agnus-Castus L. in the Japanese Market
title_fullStr Disintegration Test of Health Food Products Containing Ginkgo Biloba L. or Vitex Agnus-Castus L. in the Japanese Market
title_full_unstemmed Disintegration Test of Health Food Products Containing Ginkgo Biloba L. or Vitex Agnus-Castus L. in the Japanese Market
title_short Disintegration Test of Health Food Products Containing Ginkgo Biloba L. or Vitex Agnus-Castus L. in the Japanese Market
title_sort disintegration test of health food products containing ginkgo biloba l. or vitex agnus-castus l. in the japanese market
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533160/
https://www.ncbi.nlm.nih.gov/pubmed/28930200
http://dx.doi.org/10.3390/medicines2020047
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