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Development of New Contrast Agents for Imaging Function and Metabolism by Magnetic Resonance Imaging
Liposomes are interesting nanosystems with a wide range of medical application. One particular application is their ability to enhance contrast in magnetic resonance images; when properly loaded with magnetic/superparamagnetic nanoparticles, this means to act as contrast agents. The design of liposo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533252/ https://www.ncbi.nlm.nih.gov/pubmed/28804244 http://dx.doi.org/10.1177/1178623X17722134 |
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author | Carvalho, Alexandra Gonçalves, M Clara Corvo, M Luísa Martins, M Bárbara F |
author_facet | Carvalho, Alexandra Gonçalves, M Clara Corvo, M Luísa Martins, M Bárbara F |
author_sort | Carvalho, Alexandra |
collection | PubMed |
description | Liposomes are interesting nanosystems with a wide range of medical application. One particular application is their ability to enhance contrast in magnetic resonance images; when properly loaded with magnetic/superparamagnetic nanoparticles, this means to act as contrast agents. The design of liposomes loaded with magnetic particles, magnetoliposomes, presents a large number of possibilities depending on the application from image function to metabolism. More interesting is its double function application as theranostics (diagnostics and therapy). The synthesis, characterization, and possible medical applications of two types of magnetoliposomes are reviewed. Their performance will be compared, in particular, their efficiency as contrast agents for magnetic resonance imaging, measured by their relaxivities r(1) and r(2) relating to their particular composition. One of the magnetoliposomes had 1,2-diacyl-sn-glycero-3-phosphocholine (soy) as the main phospholipid component, with and without cholesterol, varying its phospholipid to cholesterol molar ratios. The other formulation is a long-circulating liposome composed of 1,2-diacyl-sn-glycero-3-phosphocholine (egg), cholesterol, and 1,2-distearoyl-sn-glycerol-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]. Both nanosystems were loaded with superparamagnetic iron oxide nanoparticles with different sizes and coatings. |
format | Online Article Text |
id | pubmed-5533252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-55332522017-08-11 Development of New Contrast Agents for Imaging Function and Metabolism by Magnetic Resonance Imaging Carvalho, Alexandra Gonçalves, M Clara Corvo, M Luísa Martins, M Bárbara F Magn Reson Insights Review Liposomes are interesting nanosystems with a wide range of medical application. One particular application is their ability to enhance contrast in magnetic resonance images; when properly loaded with magnetic/superparamagnetic nanoparticles, this means to act as contrast agents. The design of liposomes loaded with magnetic particles, magnetoliposomes, presents a large number of possibilities depending on the application from image function to metabolism. More interesting is its double function application as theranostics (diagnostics and therapy). The synthesis, characterization, and possible medical applications of two types of magnetoliposomes are reviewed. Their performance will be compared, in particular, their efficiency as contrast agents for magnetic resonance imaging, measured by their relaxivities r(1) and r(2) relating to their particular composition. One of the magnetoliposomes had 1,2-diacyl-sn-glycero-3-phosphocholine (soy) as the main phospholipid component, with and without cholesterol, varying its phospholipid to cholesterol molar ratios. The other formulation is a long-circulating liposome composed of 1,2-diacyl-sn-glycero-3-phosphocholine (egg), cholesterol, and 1,2-distearoyl-sn-glycerol-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]. Both nanosystems were loaded with superparamagnetic iron oxide nanoparticles with different sizes and coatings. SAGE Publications 2017-07-24 /pmc/articles/PMC5533252/ /pubmed/28804244 http://dx.doi.org/10.1177/1178623X17722134 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm). |
spellingShingle | Review Carvalho, Alexandra Gonçalves, M Clara Corvo, M Luísa Martins, M Bárbara F Development of New Contrast Agents for Imaging Function and Metabolism by Magnetic Resonance Imaging |
title | Development of New Contrast Agents for Imaging Function and Metabolism by Magnetic Resonance Imaging |
title_full | Development of New Contrast Agents for Imaging Function and Metabolism by Magnetic Resonance Imaging |
title_fullStr | Development of New Contrast Agents for Imaging Function and Metabolism by Magnetic Resonance Imaging |
title_full_unstemmed | Development of New Contrast Agents for Imaging Function and Metabolism by Magnetic Resonance Imaging |
title_short | Development of New Contrast Agents for Imaging Function and Metabolism by Magnetic Resonance Imaging |
title_sort | development of new contrast agents for imaging function and metabolism by magnetic resonance imaging |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533252/ https://www.ncbi.nlm.nih.gov/pubmed/28804244 http://dx.doi.org/10.1177/1178623X17722134 |
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