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DNA Microarray Analysis of Estrogen Responsive Genes in Ishikawa Cells by Glabridin
Based on a previous study, glabridin displayed a dose-dependent increase in estrogenic activity and cell proliferative activity in Ishikawa cells. However, when treated in combination with 17β-E(2), synergistic estrogenic effect was observed but without the same synergistic increase in cell prolifer...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533267/ https://www.ncbi.nlm.nih.gov/pubmed/28804245 http://dx.doi.org/10.1177/1178626417721676 |
Sumario: | Based on a previous study, glabridin displayed a dose-dependent increase in estrogenic activity and cell proliferative activity in Ishikawa cells. However, when treated in combination with 17β-E(2), synergistic estrogenic effect was observed but without the same synergistic increase in cell proliferative effect. This study aimed to identify the estrogen and nonestrogen-regulated activities induced by glabridin and in combination with 17β-E(2) in comparison with 17β-E(2). The results showed that 10 µM glabridin and the combination treatment of 100 nM glabridin with 1 nM 17β-E(2) regulated both the genomic and nongenomic estrogen pathways to possibly provide benefits of estrogens in cardiovascular, circulatory, and vasculature systems. Meanwhile, the combination of 100 nM glabridin with 1 nM 17β-E(2) seems to be more suitable to be used as an estrogen replacement. Finally, the results of this study have added on to the present knowledge of glabridin’s function as a phytoestrogen and suggested new ideas for the usage of glabridin. |
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