Cargando…
Ganoderma spp.: A Promising Adjuvant Treatment for Breast Cancer
For the past several decades, cancer patients in the U.S. have chosen the use of natural products as an alternative or complimentary medicine approach to treat or improve their quality of life via reduction or prevention of the side effects during or after cancer treatment. The genus Ganoderma inclu...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533290/ https://www.ncbi.nlm.nih.gov/pubmed/28758107 http://dx.doi.org/10.3390/medicines4010015 |
_version_ | 1783253596871065600 |
---|---|
author | Suárez-Arroyo, Ivette J. Loperena-Alvarez, Yaliz Rosario-Acevedo, Raysa Martínez-Montemayor, Michelle M. |
author_facet | Suárez-Arroyo, Ivette J. Loperena-Alvarez, Yaliz Rosario-Acevedo, Raysa Martínez-Montemayor, Michelle M. |
author_sort | Suárez-Arroyo, Ivette J. |
collection | PubMed |
description | For the past several decades, cancer patients in the U.S. have chosen the use of natural products as an alternative or complimentary medicine approach to treat or improve their quality of life via reduction or prevention of the side effects during or after cancer treatment. The genus Ganoderma includes about 80 species of mushrooms, of which several have been used for centuries in traditional Asian medicine for their medicinal properties, including anticancer and immunoregulatory effects. Numerous bioactive compounds seem to be responsible for their healing effects. Among the approximately 400 compounds produced by Ganoderma spp., triterpenes, peptidoglycans and polysaccharides are the major physiologically-active constituents. Ganoderma anticancer effects are attributed to its efficacy in reducing cancer cell survival and growth, as well as by its chemosensitizing role. In vitro and in vivo studies have been conducted in various cancer cells and animal models; however, in this review, we focus on Ganoderma’s efficacy on breast cancers. Evidence shows that some species of Ganoderma have great potential as a natural therapeutic for breast cancer. Nevertheless, further studies are needed to investigate their potential in the clinical setting and to translate our basic scientific findings into therapeutic interventions for cancer patients. |
format | Online Article Text |
id | pubmed-5533290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55332902017-07-28 Ganoderma spp.: A Promising Adjuvant Treatment for Breast Cancer Suárez-Arroyo, Ivette J. Loperena-Alvarez, Yaliz Rosario-Acevedo, Raysa Martínez-Montemayor, Michelle M. Medicines (Basel) Review For the past several decades, cancer patients in the U.S. have chosen the use of natural products as an alternative or complimentary medicine approach to treat or improve their quality of life via reduction or prevention of the side effects during or after cancer treatment. The genus Ganoderma includes about 80 species of mushrooms, of which several have been used for centuries in traditional Asian medicine for their medicinal properties, including anticancer and immunoregulatory effects. Numerous bioactive compounds seem to be responsible for their healing effects. Among the approximately 400 compounds produced by Ganoderma spp., triterpenes, peptidoglycans and polysaccharides are the major physiologically-active constituents. Ganoderma anticancer effects are attributed to its efficacy in reducing cancer cell survival and growth, as well as by its chemosensitizing role. In vitro and in vivo studies have been conducted in various cancer cells and animal models; however, in this review, we focus on Ganoderma’s efficacy on breast cancers. Evidence shows that some species of Ganoderma have great potential as a natural therapeutic for breast cancer. Nevertheless, further studies are needed to investigate their potential in the clinical setting and to translate our basic scientific findings into therapeutic interventions for cancer patients. MDPI 2017-03-15 /pmc/articles/PMC5533290/ /pubmed/28758107 http://dx.doi.org/10.3390/medicines4010015 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Suárez-Arroyo, Ivette J. Loperena-Alvarez, Yaliz Rosario-Acevedo, Raysa Martínez-Montemayor, Michelle M. Ganoderma spp.: A Promising Adjuvant Treatment for Breast Cancer |
title | Ganoderma spp.: A Promising Adjuvant Treatment for Breast Cancer |
title_full | Ganoderma spp.: A Promising Adjuvant Treatment for Breast Cancer |
title_fullStr | Ganoderma spp.: A Promising Adjuvant Treatment for Breast Cancer |
title_full_unstemmed | Ganoderma spp.: A Promising Adjuvant Treatment for Breast Cancer |
title_short | Ganoderma spp.: A Promising Adjuvant Treatment for Breast Cancer |
title_sort | ganoderma spp.: a promising adjuvant treatment for breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533290/ https://www.ncbi.nlm.nih.gov/pubmed/28758107 http://dx.doi.org/10.3390/medicines4010015 |
work_keys_str_mv | AT suarezarroyoivettej ganodermasppapromisingadjuvanttreatmentforbreastcancer AT loperenaalvarezyaliz ganodermasppapromisingadjuvanttreatmentforbreastcancer AT rosarioacevedoraysa ganodermasppapromisingadjuvanttreatmentforbreastcancer AT martinezmontemayormichellem ganodermasppapromisingadjuvanttreatmentforbreastcancer |