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Deciphering the regulation of P2X4 receptor channel gating by ivermectin using Markov models
The P2X4 receptor (P2X4R) is a member of a family of purinergic channels activated by extracellular ATP through three orthosteric binding sites and allosterically regulated by ivermectin (IVM), a broad-spectrum antiparasitic agent. Treatment with IVM increases the efficacy of ATP to activate P2X4R,...
Autores principales: | Mackay, Laurent, Zemkova, Hana, Stojilkovic, Stanko S., Sherman, Arthur, Khadra, Anmar |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533465/ https://www.ncbi.nlm.nih.gov/pubmed/28708827 http://dx.doi.org/10.1371/journal.pcbi.1005643 |
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