Transcriptome profiling of monocytes from XLA patients revealed the innate immune function dysregulation due to the BTK gene expression deficiency

X-linked agammaglobulinemia (XLA) is a rare genetic disorder, caused by mutations in BTK (Bruton’s Tyrosine Kinase) gene. Deep high-throughput RNA sequencing (RNA-Seq) approach was utilized to explore the possible differences in transcriptome profiles of primary monocytes in XLA patients compared wi...

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Detalles Bibliográficos
Autores principales: Mirsafian, Hoda, Ripen, Adiratna Mat, Leong, Wai-Mun, Chear, Chai Teng, Bin Mohamad, Saharuddin, Merican, Amir Feisal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533715/
https://www.ncbi.nlm.nih.gov/pubmed/28754963
http://dx.doi.org/10.1038/s41598-017-06342-5

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