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Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates

Aggregation of TDP-43 (transactive response DNA binding protein 43 kDa) is a hallmark of certain forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Moreover, intracellular TDP-43-positive inclusions are often found in other neurodegenerative diseases. Recently...

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Detalles Bibliográficos
Autores principales:	Garnier, Cyrille, Devred, François, Byrne, Deborah, Puppo, Rémy, Roman, Andrei Yu., Malesinski, Soazig, Golovin, Andrey V., Lebrun, Régine, Ninkina, Natalia N., Tsvetkov, Philipp O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533730/ https://www.ncbi.nlm.nih.gov/pubmed/28754988 http://dx.doi.org/10.1038/s41598-017-07215-7

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