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A novel proton transfer mechanism in the SLC11 family of divalent metal ion transporters
In humans, the H(+)-coupled Fe(2+) transporter DMT1 (SLC11A2) is essential for proper maintenance of iron homeostasis. While X-ray diffraction has recently unveiled the structure of the bacterial homologue ScaDMT as a LeuT-fold transporter, the exact mechanism of H(+)-cotransport has remained elusiv...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533754/ https://www.ncbi.nlm.nih.gov/pubmed/28754960 http://dx.doi.org/10.1038/s41598-017-06446-y |